Amifostine use in radiation-induced kidney damage

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dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authoridPARLAR, SULE/0000-0001-9422-853X
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.contributor.authorKaldir, Mine
dc.contributor.authorCosar-Alas, Rusen
dc.contributor.authorCermik, Tevfik Fikret
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorSaynak, Mert
dc.contributor.authorAltaner, Semsi
dc.contributor.authorCaloglu, Murat
dc.date.accessioned2024-06-12T10:51:24Z
dc.date.available2024-06-12T10:51:24Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To assess the degree of protective effects of amifostine on kidney functions via semiquantitative static renal scintigraphy and histopathologic analysis. Material and Methods: 30 female albino rats were divided into three equal groups as control (CL), radiotherapy alone (RT), and radiotherapy + amifostine (RT+AMI). The animals in the CL and RT groups were given phosphate-buffered saline, whereas the animals in the RT+AMI group received amifostine (200 mg/kg) by intraperitoneal injection 30 min before irradiation. RT and RT+AMI groups were irradiated with a single dose of 6 Gy using a Co-60 unit at a source-skin distance of 80 cm to the whole right kidney. They were followed up for 6 months. CL, RT, and RT+AMI groups underwent static kidney scintigraphy at the beginning of the experiment and, again, on the day before sacrificing. Histopathologically, tubular atrophy and fibrosis of the kidney damage were evaluated. Results: After irradiation, the median value of right kidney function was 48% (44-49%) and 50.5% (49%-52%) in RT and RT+AMI groups, respectively (p = 0.0002). Grade 1 kidney fibrosis was observed to be 60% in the RT group, while it was only 30% in the RT+AMI group. Grade 2 kidney fibrosis was 30% and 0% in the RT and RT+AMI group, respectively. Grade 1 tubular atrophy was 70% and 50% in the RT and RT+AMI group, respectively. Grade 2 tubular atrophy effect was the same in both groups (10%). Conclusion: Static kidney scintigraphy represents an objective and reproducible method to noninvasively investigate kidney function following irradiation. Amifostine produced a significant reduction in radiation-induced loss of renal function.en_US
dc.identifier.doi10.1007/s00066-008-1777-7
dc.identifier.endpage375en_US
dc.identifier.issn0179-7158
dc.identifier.issn1439-099X
dc.identifier.issue7en_US
dc.identifier.pmid19016036en_US
dc.identifier.scopus2-s2.0-56549091749en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage370en_US
dc.identifier.urihttps://doi.org/10.1007/s00066-008-1777-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18358
dc.identifier.volume184en_US
dc.identifier.wosWOS:000257588600005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofStrahlentherapie Und Onkologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmifostineen_US
dc.subjectRadiation Nephropathyen_US
dc.subjectKidney Scintigraphyen_US
dc.subjectRadiation Late Effectsen_US
dc.subjectAbdominal Radiotherapyen_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectRenal-Functionen_US
dc.subjectEnd-Pointsen_US
dc.subjectNephropathyen_US
dc.subjectIrradiationen_US
dc.subjectInjuryen_US
dc.subjectToxicityen_US
dc.subjectMouseen_US
dc.subjectTc-99m-Dmsaen_US
dc.titleAmifostine use in radiation-induced kidney damageen_US
dc.typeArticleen_US

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