Molecular Pattern and Clinical Implications of KRAS/NRAS and BRAF Mutations in Colorectal Cancer

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dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.authoridTastekin, Ebru/0000-0002-7686-7765
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridDEMIR, NAZAN/0009-0000-2988-4450
dc.authorwosidHacioglu, Bekir/GZH-1824-2022
dc.contributor.authorGokmen, Ivo
dc.contributor.authorTastekin, Ebru
dc.contributor.authorDemir, Nazan
dc.contributor.authorOzcan, Erkan
dc.contributor.authorAkgul, Fahri
dc.contributor.authorHacioglu, Muhammed Bekir
dc.contributor.authorErdogan, Bulent
dc.date.accessioned2024-06-12T11:07:25Z
dc.date.available2024-06-12T11:07:25Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of our study was to evaluate the incidence of KRAS/NRAS and BRAF mutations, analyze molecular patterns, and investigate associations with clinical parameters of these mutations in CRC KRAS/NRAS and BRAF mutations analyzed by next-generation sequencing. The detection rates of these mutations and patients' demographics were recorded and the relationship between them was evaluated using the chi-square test. KRAS mutation was detected in 332 of 694 patients, while the mutation rates in KRAS exons 2/3 and 4 were 39.6%/3.2% and 5%, respectively. The most common mutation pattern was KRAS G12D. Five atypical variants were detected: V14I in KRAS exon 2, A18D, Q22K and T50I in exon 3, and T148P in exon 4. NRAS mutation was detected in 29 (4.5%) patients. One atypical variant L80W was detected in NRAS exon 3. BRAF mutation was seen in 37 (5.3%) patients, with BRAF(V600E) (83.8%) being the most common mutation pattern. NRAS mutation was significantly more frequent in patients > 64 years of age, BRAF mutation in women, and NRAS/BRAF mutations in right colon tumors. Grouping BRAF mutations into BRAF(V600E) and BRAF(non-V600E) and their analysis according to specific tumor localizations showed that all four BRAF(non-V600E) mutations originated in the rectum. In our study, KRAS exon 2 and other RAS mutation rates were higher than in the literature, while the BRAF v.600E mutation rate was similar. NRAS and BRAF mutations were significantly more frequent in the right colon. BRAF mutation was more common in women and in the right colon.en_US
dc.identifier.doi10.3390/cimb45100491
dc.identifier.endpage7812en_US
dc.identifier.issn1467-3037
dc.identifier.issn1467-3045
dc.identifier.issue10en_US
dc.identifier.pmid37886935en_US
dc.identifier.scopus2-s2.0-85175074595en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage7803en_US
dc.identifier.urihttps://doi.org/10.3390/cimb45100491
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22030
dc.identifier.volume45en_US
dc.identifier.wosWOS:001098213700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofCurrent Issues In Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKRASen_US
dc.subjectNRASen_US
dc.subjectBRAFen_US
dc.subjectMutationen_US
dc.subjectNGSen_US
dc.subjectColorectal Canceren_US
dc.subjectPlus Cetuximab Treatmenten_US
dc.subject1st-Line Treatmenten_US
dc.subjectRas Mutationsen_US
dc.subjectPooled Analysisen_US
dc.subjectKrasen_US
dc.subjectFluorouracilen_US
dc.subjectLeucovorinen_US
dc.subjectPrevalenceen_US
dc.subjectCarcinomaen_US
dc.subjectGeneen_US
dc.titleMolecular Pattern and Clinical Implications of KRAS/NRAS and BRAF Mutations in Colorectal Canceren_US
dc.typeArticleen_US

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