Cognitive dysfunction in patients with chronic obstructive pulmonary disease

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dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorPekel, Nilufer Buyukkoyuncu
dc.contributor.authorTurgut, Nilda
dc.contributor.authorAltiay, Gundeniz
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorTurgut, Burhan
dc.contributor.authorErbas, Hakan
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:56:31Z
dc.date.available2024-06-12T10:56:31Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Chronic obstructive pulmonary disease (COPD) is characterized with air flow limitation. Cognitive problems can appear in advanced stage of COPD. There is relationship between COPD and levels of homocystein (hcy) and total antioxidant capacity (TAC). There is also relationship between cognitive dysfunction and levels of hcy and TAC. We aimed evaluation of cognitive functions in patients with COPD, and demonstration of the relationship between cognitive function and hcy and TAC. Methods: Twenty-eight hypoxic (group 1), 28 non-hypoxic COPD patients (group 2) and 25 healthy people (control group, group 3) were included to study. Hcy and TAC levels were measured in all subjects. Cognitive functions were evaluated in all subjects with standardized mini mental test (SMMT), clock drawing test (CDT), Blessed orientation memory concentration test (BOMCT), Benton's facial recognition test (BFRT) and clinical dementia rating scale (CDRS). Results: Hcy levels were high in group 1 (p=0.004), TAC levels were high in group 1 and 2 (p=0.04). SMMT (p=0.000) and CDT values were low in group1 (p=0.000), CDRS values were high in group1 and 2 (p=0.000), BFRT values were low in group1 and 2 (p=0.000), BOMCT values were high in group1 (p=0.000). There were a correlation between TAC and SMMT (r=0.582, p=0.001) and CDRS (r=-0.384, p=0.044). Conclusions: We demonstrated presence of cognitive dysfunction in COPD patients. Patients with hypoxic had more profound cognitive dysfunction. In addition, we demonstrated a relationship between TAC and cognitive dysfunction.en_US
dc.identifier.doi10.5350/BTDMJB.20171228110902
dc.identifier.endpage114en_US
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85044762055en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage109en_US
dc.identifier.trdizinid287671en_US
dc.identifier.urihttps://doi.org/10.5350/BTDMJB.20171228110902
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/287671
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19808
dc.identifier.volume14en_US
dc.identifier.wosWOS:000431943800017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A Sen_US
dc.relation.ispartofMedical Journal Of Bakirkoyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Obsructive Pulmonary Diseaseen_US
dc.subjectCognitive Testsen_US
dc.subjectHomocysteineen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectOxidative Stressen_US
dc.subjectAlzheimers-Diseaseen_US
dc.subjectHomocysteineen_US
dc.subjectCopden_US
dc.subjectAntioxidantsen_US
dc.subjectImpairmenten_US
dc.subjectPerformanceen_US
dc.subjectPopulationen_US
dc.subjectApoptosisen_US
dc.subjectSmokingen_US
dc.titleCognitive dysfunction in patients with chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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