Gamma knife radiosurgery for pituitary spindle cell oncocytomas

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dc.authoridPeker, Selcuk/0000-0003-3057-3355
dc.authoridHergunsel, Omer Batu/0000-0003-3143-0575
dc.authorwosidPeker, Selcuk/D-2516-2015
dc.authorwosidPeker, Selcuk/JBJ-5917-2023
dc.contributor.authorAkyoldas, Goktug
dc.contributor.authorHergunsel, Omer Batu
dc.contributor.authorOzdemir, Inan Erdem
dc.contributor.authorSengoz, Meric
dc.contributor.authorPeker, Selcuk
dc.date.accessioned2024-06-12T11:15:31Z
dc.date.available2024-06-12T11:15:31Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Spindle cell oncocytomas (SCOs) are benign lesions of the posterior portion of the pituitary gland that typically come to neurosurgical attention due to compression of the sellar or parasellar structures, and headaches. Initial treatment options for SCOs include surgical resection, particularly via the transsphenoidal approach. However, given that initial resection tends to be insufficient and subsequent revision surgery carries high complication risk, adjuvant treatment modalities may appear to offer promising solutions for controlling tumor progression. This report focuses on a potential new therapeutic option for SCOs, gamma knife radiosurgery (GKRS). Patients and methods: The authors identified all patients at one center who had a pituitary lesion treated with GKRS between 2005 and 2016. Five patients with histopathologically confirmed SCO who underwent GKRS were retrospectively identified and included in the present study Results: The mean patient age was 52 years (range, 41-61 years). The most common presenting symptom was visual disturbance. All five patients had a history of transsphenoidal surgical resection prior to GKRS therapy. The mean tumor volume was 2.25 cm(3) (range 0.7-5.38 cm(3)). The median tumor margin dose was 12 Gy (range, 12-14 Gy), and the median maximal dose was 24 Gy (range, 24-35 Gy). The median isodose was 50 (range, 40-50). No tumor volume progression was observed during radiological follow-up after GKRS (mean, 52 months; range, 36-84 months). At last follow-up, no neurological, endocrinological, or visual complications had been observed. Conclusion: Given their highly vascular and adherent nature, SCOs can be challenging tumors to treat, in particular when they recur. In our five cases, GKRS provided excellent tumor volume control for approximately 4.3 years on average. These results suggest that GKRS is a safe and effective treatment modality for histopatholo-gically confirmed residual SCO.en_US
dc.identifier.doi10.1016/j.clineuro.2019.105560
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.pmid31648114en_US
dc.identifier.scopus2-s2.0-85073514535en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2019.105560
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23970
dc.identifier.volume187en_US
dc.identifier.wosWOS:000500365200009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinical Neurology And Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpindle Cellen_US
dc.subjectOncocytomasen_US
dc.subjectSellaren_US
dc.subjectMassen_US
dc.subjectPituitaryen_US
dc.subjectTranssphenoidalen_US
dc.subjectRevisionen_US
dc.subjectStereotactic Radiosurgeryen_US
dc.subjectGamma Knifeen_US
dc.subjectOncologyen_US
dc.subjectEndoscopic Endonasal Surgeryen_US
dc.subjectRepeat Transsphenoidal Surgeryen_US
dc.subjectAdenohypophysis Reporten_US
dc.subjectRecurrenten_US
dc.subjectAdenomasen_US
dc.subjectExperienceen_US
dc.subjectTumorsen_US
dc.titleGamma knife radiosurgery for pituitary spindle cell oncocytomasen_US
dc.typeArticleen_US

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