Effects of exogenous melatonin on myoglobinuric acute renal failure in the rats

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.contributor.authorAydogdu, N
dc.contributor.authorAtmaca, G
dc.contributor.authorYalcin, O
dc.contributor.authorBatcioglu, K
dc.contributor.authorKaymak, K
dc.date.accessioned2024-06-12T11:08:15Z
dc.date.available2024-06-12T11:08:15Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFree oxygen radicals and nitric oxide (NO) play a crucial role in the pathogenesis of myoglobinuric acute renal failure (ARF). In this study, we aimed to investigate the effect of melatonin, a potent free radical scavenger, on the myoglobinuric ARF formed by injecting hypertonic glycerol intramuscularly (im). The rats were randomly divided into 4 Groups. Rats in Group 1 were given saline and those in Groups 2, 3, and 4 were injected with glycerol (10 mL/kg) im. Concomitant and 24 hours after glycerol injection Group 3 (5 mg/kg) and Group 4 (10 mg/kg) were administrated melatonin intraperitoneally. Forty-eight hours after the glycerol injection, the blood and kidneys of the rats were taken under anesthesia. Kidney morphology and the levels of urea, creatinine and nitric oxide metabolites (NOx) in the plasma and the enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the level of malondialdehyde (MDA) in the kidney were determined. In both groups of melatonin administration, there was no protective effect of melatonin. Moreover, melatonin significantly decreased the level of NO. As a result, we suggest that the decreasing effect of melatonin on NO, which is a strong vasodilatator, may further increase the renal ischemia in this model. Thus, melatonin may have worsening rather than beneficial effects on myoglobinuric ARF.en_US
dc.identifier.doi10.1081/JDI-200033020
dc.identifier.endpage486en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue5en_US
dc.identifier.pmid15526905en_US
dc.identifier.scopus2-s2.0-5444262957en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1081/JDI-200033020
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22364
dc.identifier.volume26en_US
dc.identifier.wosWOS:000224501400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectMyoglobinuric Acute Renal Failureen_US
dc.subjectNitric Oxideen_US
dc.subjectLipid Peroxidationen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectNitric-Oxideen_US
dc.subjectAntioxidant Protectsen_US
dc.subjectVitamin-Een_US
dc.subjectRhabdomyolysisen_US
dc.subjectInjuryen_US
dc.subjectNephrotoxicityen_US
dc.subjectPreventsen_US
dc.subjectIronen_US
dc.titleEffects of exogenous melatonin on myoglobinuric acute renal failure in the ratsen_US
dc.typeArticleen_US

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