Effects of methylene blue in acute lung injury induced by blunt schest trauma

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dc.authorscopusid6507986716
dc.authorscopusid16443917200
dc.authorscopusid22985194700
dc.authorscopusid55970945900
dc.authorscopusid23398341000
dc.authorscopusid56576122400
dc.authorscopusid57197076282
dc.contributor.authorAyvaz S.
dc.contributor.authorAksu B.
dc.contributor.authorKaraca T.
dc.contributor.authorCemek M.
dc.contributor.authorTarladacalisir Y.-T.
dc.contributor.authorAyaz A.
dc.contributor.authorMetin M.-S.
dc.date.accessioned2024-06-12T10:28:31Z
dc.date.available2024-06-12T10:28:31Z
dc.date.issued2014
dc.description.abstractBackground: We studied whether methylene blue (MB) treatment blunts chest trauma-induced lung injury in rats. Material and Methods: Forty male Sprague-Dawley rats, 200-300g, were used. The rats were divided into five groups (n=8): control, early contusion (EC), early contusion + methylene blue (2 mg/kg, EC+MB), late contusion (LC), and late contusion + methylene blue (2 mg/kg, LC+MB). Results: Histopathological analysis showed increased hemorrhage, alveolar wall thickness, edema, and inflammatory cell infiltrates in the EC and LC rats, which decreased upon MB treatment. Immunohistochemical studies revealed that MB reduced activation of inducible nitric oxide synthase (iNOS) and the number of active terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells. A significant increase was observed in the malondialdehyde (MDA) and nitric oxide (NO) levels in the EC group compared to the control group (p<0.05). In addition, a significant decrease was reported in the glutathione (GSH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) levels (p<0.01), but no significant difference was observed in the catalase (CAT) levels among the groups. The MDA level was significantly higher in the LC group compared to the control group, whereas the GSH level was significantly lower compared to the control group. The NO level in the EC+MB group was significantly lower when compared to the NO level in the EC group (p<0.05). Conclusion: The present study provides evidence that MB might serve as a therapeutic treatment for blunt chest trauma.en_US
dc.identifier.endpage56en_US
dc.identifier.issn1108-4189
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84899419169en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17261
dc.identifier.volume18en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHippokratia General Hospital of Thessalonikien_US
dc.relation.ispartofHippokratiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidants; Blunt Chest Trauma; Contusion; Methylene Blue; Oxidantsen_US
dc.subjectCatalase; Glutathione; Glutathione Peroxidase; Inducible Nitric Oxide Synthase; Malonaldehyde; Methylene Blue; Nitric Oxide; Superoxide Dismutase; Acute Lung Injury; Alveolar Wall Thickness; Animal Cell; Animal Experiment; Animal Model; Animal Tissue; Article; Controlled Study; Drug Effect; Enzyme Activation; Histopathology; Immunohistochemistry; Inflammatory Infiltrate; Lung Contusion; Lung Edema; Lung Hemorrhage; Male; Nick End Labeling; Nonhuman; Oxidative Stress; Rat; Respiratory Tract Parameters; Thorax Blunt Traumaen_US
dc.titleEffects of methylene blue in acute lung injury induced by blunt schest traumaen_US
dc.typeArticleen_US

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