Clinical characteristics, quality of life and risk factors for severity in palmoplantar pustulosis: a cross-sectional, multicentre study of 263 patients

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dc.authoridSarikaya Solak, Sezgi/0000-0002-8572-8249
dc.authoridYilmaz, Oguz/0000-0001-8454-4811
dc.authorwosidKaradag, Ayse Serap/V-7974-2018
dc.authorwosidGönülal, Melis/ABW-6872-2022
dc.authorwosidSarikaya Solak, Sezgi/A-4789-2016
dc.authorwosidPolat Ekinci, Algün/JDW-8990-2023
dc.contributor.authorSolak, S. Sarikaya
dc.contributor.authorPolat, A. Kara
dc.contributor.authorKilic, S.
dc.contributor.authorTopal, I. Oguz
dc.contributor.authorSaricaoglu, H.
dc.contributor.authorKaradag, A. S.
dc.contributor.authorCanpolat, F.
dc.date.accessioned2024-06-12T11:19:44Z
dc.date.available2024-06-12T11:19:44Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Palmoplantar pustulosis (PPP) is a rare, chronic, inflammatory skin disease characterized by sterile pustules on palmar or plantar areas. Data on PPP are scarce. Aim To investigate the clinical characteristics and risk factors for disease severity in a large cohort of Turkish patients with PPP. Methods We conducted a cross-sectional, multicentre study of patients with PPP recruited from 21 tertiary centres across Turkey. Results In total, 263 patients (165 women, 98 men) were evaluated. Most patients (75.6%) were former or current smokers. The mean Palmoplantar Pustulosis Area and Severity Index (PPPASI) was 8.70 +/- 8.06 and the mean Dermatology Life Quality Index (DLQI) score was 6.87 +/- 6.08, and these scores were significantly correlated (r = 0.52, P < 0.001). Regression analysis showed that current smoking was significantly associated with increased PPPASI (P = 0.03). Coexisting psoriasis vulgaris (PsV) was reported by 70 (26.6%) patients. Male sex prevalence, PPP onset incidence, disease duration, DLQI, and prevalence of nail involvement and psoriatic arthritis (PsA) were significantly increased among patients with PPP with PsV. Of the 263 patients, 18 (6.8%) had paradoxical PPP induced by biologic therapy, and these patients had significantly increased mean DLQI and prevalence of PsA (r = 0.03, P = 0.001). Conclusion Our data suggest that smoking is a risk factor for both PPP development and disease severity. Patients with PPP with PsV present distinct clinical features and patients with biologic therapy-induced paradoxical PPP have reduced quality of life and are more likely to have PsA.en_US
dc.identifier.doi10.1111/ced.14829
dc.identifier.endpage71en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue1en_US
dc.identifier.pmid34236713en_US
dc.identifier.scopus2-s2.0-85113312042en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1111/ced.14829
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25311
dc.identifier.volume47en_US
dc.identifier.wosWOS:000688158400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical And Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriasisen_US
dc.subjectComorbiditiesen_US
dc.subjectPlantarisen_US
dc.subjectPalmarisen_US
dc.titleClinical characteristics, quality of life and risk factors for severity in palmoplantar pustulosis: a cross-sectional, multicentre study of 263 patientsen_US
dc.typeArticleen_US

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