Protective effect of quercetin on liver damage induced by biliary obstruction in rats

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:13:20Z
dc.date.available2024-06-12T11:13:20Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the possible protective effects of quercetin (QE) against cholestatic oxidative stress and liver damage in the common bile duct ligated rats. A total of 24 male Wistar albino rats were divided into three groups: control, bile duct ligation (BDL) and BDL + received QE; each group contain 8 animals. The rats in QE treated groups were given QE (15 mg/kg) once a day intraperitoneally for 4 weeks starting 3 days prior to BDL operation. The changes demonstrating the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, mononuclear cells, and neutrophil infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with QE attenuated alterations in liver histology. The alpha smooth muscle actin (alpha-SMA), transforming growth factor beta (TGF-beta 1) positive cells and the activity of TUNEL in the BDL were observed to be reduced with the QE treatment. The data indicate that QE attenuates BDL-induced cholestatic liver injury, bile duct proliferation, and fibrosis. The hepatoprotective effect of QE is associated with antioxidative potential.en_US
dc.identifier.doi10.1007/s10735-010-9301-7
dc.identifier.endpage402en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue6en_US
dc.identifier.pmid20960038en_US
dc.identifier.scopus2-s2.0-78649903644en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-010-9301-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23494
dc.identifier.volume41en_US
dc.identifier.wosWOS:000288453200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQuercetinen_US
dc.subjectImmunohistochemistryen_US
dc.subjectTUNELen_US
dc.subjectLiveren_US
dc.subjectBile Duct Ligationen_US
dc.subjectGrowth-Factor-Betaen_US
dc.subjectBile-Duct Ligationen_US
dc.subjectTgf-Betaen_US
dc.subjectHepatic-Fibrosisen_US
dc.subjectExpressionen_US
dc.subjectFlavonoidsen_US
dc.subjectCirrhosisen_US
dc.subjectCellsen_US
dc.subjectInhibitorsen_US
dc.subjectIncreasesen_US
dc.titleProtective effect of quercetin on liver damage induced by biliary obstruction in ratsen_US
dc.typeArticleen_US

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