Thymoquinone reestablishes spermatogenesis after testicular injury caused by chronic toluene exposure in rats

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:16:29Z
dc.date.available2024-06-12T11:16:29Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was designed to evaluate the possible protective effects of thymoquinone (TQ) on the spermatogenesis after testicular injury caused by chronic toluene exposure in rats. The rats were randomly allotted into one of three experimental groups: control, toluene-treated and toluene treated with TQ; each group contained 10 animals. Control group received 1 mL serum physiologic and toluene treatment was performed by inhalation of 3000 ppm toluene, in an 8-hour/day and 6-day/week order for 12 weeks. The rats in TQ-treated group was given TQ (50 mg/kg body weight) once a day orally for 12 weeks starting just after toluene exposure. Tissue samples were obtained for histopathological investigation. To date, no histopathological changes of testis in rats after chronic toluene exposure by TQ treatment have been reported. Spermatogenesis and mean seminiferous tubule diameter (MSTD) were significantly decreased in toluene treated groups when compared to the control group. Furthermore, the TQ-treated animals showed an improved histological appearance in toluene-treated group. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling (TUNEL), endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS) and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of the toluene-treated group with TQ therapy. Electron microscopy of the testes of the rats demonstrated that pretreatment with TQ was particularly effective in preventing the mitochondrial degeneration, dilatation of smooth endoplasmic reticulum (SER) and enlarged intercellular spaces in both Sertoli and spermatid cells in the toluene-treated animals. We believe that further preclinical research into the utility of TQ may indicate its usefulness as a potential treatment on the spermatogenesis after testicular injury caused by chronic toluene exposure in rats.en_US
dc.identifier.doi10.1177/0748233710382541
dc.identifier.endpage166en_US
dc.identifier.issn0748-2337
dc.identifier.issue2en_US
dc.identifier.pmid20837561en_US
dc.identifier.scopus2-s2.0-79952288495en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.1177/0748233710382541
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24335
dc.identifier.volume27en_US
dc.identifier.wosWOS:000287672200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTolueneen_US
dc.subjectThymoquinoneen_US
dc.subjectTUNELen_US
dc.subjectEnosen_US
dc.subjectInosen_US
dc.subjectPCNAen_US
dc.subjectTestisen_US
dc.subjectGerm-Cell Apoptosisen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectPaint Thinner Exposureen_US
dc.subjectAntitumor-Activityen_US
dc.subjectNigella-Sativaen_US
dc.subjectOrganic-Solventsen_US
dc.subjectVolatile Oilen_US
dc.subjectTestisen_US
dc.subjectMiceen_US
dc.subjectInhibitionen_US
dc.titleThymoquinone reestablishes spermatogenesis after testicular injury caused by chronic toluene exposure in ratsen_US
dc.typeArticleen_US

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