The first case of peripheral T cell lyphoma with a CSF3R variant resulted in relapsing febrile neutropenia and aplastic anemia

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dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.contributor.authorKirkizlar, Onur
dc.contributor.authorCan, Nuray
dc.date.accessioned2024-06-12T10:58:56Z
dc.date.available2024-06-12T10:58:56Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractColony-stimulating factor 3 receptor (CSF3R) gene mutations have been previously identified in chronic neutrophilic leukemia, atypical chronic myeloid leukemia, chronic myelomonocytic leukemia, de novo acute myeloid leukemia, and severe congenital neutropenia, although there is limited data regarding lymphoid malignancies. Here, we present the first case of peripheral T cell lymphoma with CSF3R variant that developed persistent neutropenia in the follow-up visit and aplastic anemia after autologous hematopoietic stem cell transplantation. Next-generation sequencing (NGS) was performed on bone marrow aspiration (Qiagen clinical insight-QCI (TM)). CSF3R single nucleotide variant (transcript variant 4), 46.0% (of 1081 reads) of variant allele fraction on exon 16 (lying to intronic region), nucleotide NM_172313.3, g36932463A > g, c.2041-35 T > C was identified by NGS. The case study presented here is an example of use of NGS in diagnosis, classification, prognostic or response indicator of hematologic malignancies, and identification of targeted therapy options in clinical practice. Additional work is needed to understand the clinical significance of this mutation.en_US
dc.identifier.doi10.1007/s12308-022-00513-8
dc.identifier.endpage248en_US
dc.identifier.issn1868-9256
dc.identifier.issn1865-5785
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85137499284en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://doi.org/10.1007/s12308-022-00513-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20254
dc.identifier.volume15en_US
dc.identifier.wosWOS:000850405400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal Of Hematopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCSF3Ren_US
dc.subjectPeripheral T Cell Lymphomaen_US
dc.subjectFebrile Neutropeniaen_US
dc.subjectAplastic Anemiaen_US
dc.subjectMutationsen_US
dc.subjectOrganizationen_US
dc.titleThe first case of peripheral T cell lyphoma with a CSF3R variant resulted in relapsing febrile neutropenia and aplastic anemiaen_US
dc.typeArticleen_US

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