Radiotherapy and stroke

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dc.authorscopusid16246543600
dc.authorscopusid17134420400
dc.authorscopusid17134222600
dc.authorscopusid56253262800
dc.authorscopusid6507030833
dc.contributor.authorSaynak M.
dc.contributor.authorÇalo?lu V.Y.
dc.contributor.authorAlas R.C.
dc.contributor.authorÇalo?lu M.
dc.contributor.authorUzal C.
dc.date.accessioned2024-06-12T10:29:24Z
dc.date.available2024-06-12T10:29:24Z
dc.date.issued2007
dc.description.abstractCerebrovascular disease is common in cancer patients. Treatment of cancer including chemotherapy, surgery, radiotherapy and hormone therapy may also increase the risk of stroke. The consequences of radiation induced carotid injury can be severe and lifethreatening and have significant impact on the quality of life of patients. Radiation-induced vascular disease is believed to be a result of premature atherosclerotic changes in the arterial wall, including endothelial cell damage, subintimal fibrosis and hypertrophy, thinning and fragmentation of the elastic membrane, and thickening and fibrosis of the muscularis. The results of recent studies showed that in patients with breast cancer supraclavicular radiotherapy wasn't associated with elevated risk of ischemic stroke with modern radiotherapy techniques. The long-term sequelae of radiation exposure of the carotid arteries may take years to manifest clinically. Hypertension, diabetes, hypercholesterolemia and obesity are known to exacerbate the severity of carotid radiation injury. Effective management of these modifiable factors can halt or slow the development of carotid stenosis. Therapeutic options consist of percutaneous transluminal angioplasty, carotid endarteriectomy, and bypass surgery.en_US
dc.identifier.endpage117en_US
dc.identifier.issn1306-133X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-34447512810en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17746
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofUHOD - Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotid Stenosis; Cerebrovascular Disorders; Head And Neck Cancer; Radiotherapy After-Complications; Strokeen_US
dc.subjectAntineoplastic Agent; Hormone Derivative; Artery Wall; Atherosclerosis; Bypass Surgery; Cancer Patient; Cancer Radiotherapy; Carotid Artery Injury; Carotid Artery Obstruction; Carotid Endarterectomy; Cell Damage; Cerebrovascular Accident; Cerebrovascular Disease; Diabetes Mellitus; Disease Exacerbation; Disease Severity; Endothelium Cell; Fibrosis; Human; Hypercholesterolemia; Hypertension; Hypertrophy; Intima; Obesity; Percutaneous Transluminal Angioplasty; Quality Of Life; Radiation Exposure; Review; Risk Assessment; Stroke; Vascular Diseaseen_US
dc.titleRadiotherapy and strokeen_US
dc.title.alternativeRadyoterapi ve i?nmeen_US
dc.typeReview Articleen_US

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