Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:16:28Z
dc.date.available2024-06-12T11:16:28Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was designed to investigate the possible beneficial effects of Nigella sativa (NS) and derived thymoquinone (TQ) on neurodegeneration in hippocampus after chronic toluene exposure in rats. The rats were randomly allotted into one of four experimental groups: A (control), B (toluene treated), C (toluene treated with NS) and D (toluene treated with TQ); each group contain 10 animals. Toluene treatment was performed by inhalation of 3,000 ppm toluene, in a 8 h/day and 6 day/week order for 12 weeks. Control group received 1 ml serum physiologic and the rats in NS and TQ treated groups (C and D) were given NS (in a dose of 400 mg/kg body weight) and TQ (50 mg/kg body weight) once a day orally by using intra gastric intubation for 12 weeks starting just after toluene exposure respectively. Tissue samples were obtained for histopathological investigation. To date, no histopathological changes of neurodegeneration in hippocampus after chronic toluene exposure in rats by NS and TQ treatment have been reported. In this study, chronic toluene exposure caused severe degenerative changes, shrunken cytoplasma, slightly dilated cisternae of endoplasmic reticulum, markedly swollen mitochondria with degenerated cristae and nuclear membrane breakdown with chromatin disorganization in neurons of the hippocampus. The distorted nerve cells were mainly absent in the TQ and NS-treated rats. We conclude that TQ and especially NS therapy causes morphologic improvement on neurodegeneration in hippocampus after chronic toluene exposure in rats. We believe that further preclinical research into the utility of NS and TQ may indicate its usefulness as a potential treatment on neurodegeneration after chronic toluene exposure in rats.en_US
dc.identifier.doi10.1007/s11064-007-9481-z
dc.identifier.endpage588en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue3en_US
dc.identifier.pmid17929168en_US
dc.identifier.scopus2-s2.0-38949116268en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.1007/s11064-007-9481-z
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24332
dc.identifier.volume33en_US
dc.identifier.wosWOS:000252977200028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTolueneen_US
dc.subjectNigella Sativaen_US
dc.subjectThymoquinoneen_US
dc.subjectMorphologyen_US
dc.subjectHippocampusen_US
dc.subjectRatsen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectPrenatal Stressen_US
dc.subjectDevelopmental Toxicityen_US
dc.subjectOrganic-Solventsen_US
dc.subjectBiphasic Changesen_US
dc.subjectMotor-Activityen_US
dc.subjectOilen_US
dc.subjectInhalationen_US
dc.subjectProtectsen_US
dc.subjectNeuronsen_US
dc.titleNigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in ratsen_US
dc.typeArticleen_US

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