PECAM-1 gene polymorphisms and soluble PECAM-1 level in rheumatoid arthritis and systemic lupus erythematosus patients: any link with clinical atherosclerotic events?

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridYazar, Metin/0000-0002-2657-3072
dc.authorwosidUyanik, Mehmet/AAD-7345-2020
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidYazar, Metin/ABA-3934-2020
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorTozkir, Hilmi
dc.contributor.authorUyanik, Mehmet Sevki
dc.contributor.authorGurkan, Hakan
dc.contributor.authorSaritas, Fatih
dc.contributor.authorDuymaz, Julide
dc.contributor.authorDonmez, Salim
dc.date.accessioned2024-06-12T11:12:09Z
dc.date.available2024-06-12T11:12:09Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractGenetic polymorphisms of platelet endothelial cell adhesion molecule-1 (PECAM-1) were found to play roles in atherosclerotic events. We determined PECAM-1 polymorphisms, soluble PECAM-1, and CD40L levels in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and evaluated their associations with clinical atherosclerotic complications. We included 100 RA patients, 81 SLE patients, and 94 healthy controls. The clinical features about the patients were obtained from medical records. Past cardiovascular complications were recorded. The most frequent gene polymorphisms of PECAM-1 were studied in our genetics laboratory. Soluble PECAM-1 and CD40L levels in serum were determined with ELISA. The frequencies of 373C (rs668) and 1688A (rs12953) alleles were higher in RA patients when compared to controls (p values, 0.028 and 0.016). RA and SLE patients had significantly higher allele frequencies for 2008A (rs1131012) when compared to controls (p values, 0.016 and 0.001). SLE patients had significantly more frequent AA genotype for rs1131012 polymorphism than RA patients and controls (p values, 0.007 and < 0.001). Soluble PECAM-1 level was significantly higher in RA patients than in SLE patients and healthy controls (p values < 0.001). Atherosclerotic complications were more frequent in SLE patients with AG genotype (rs12953) than those with AA genotype (p = 0.021). SLE patients with CC genotype (rs668) had a significantly lower frequency of atherosclerotic complications than those with CG genotype (p = 0.045). Nevertheless, in multivariate analysis, there was no association between genotype and atherosclerotic complications. We found associations between various PECAM-1 polymorphisms in RA and SLE; PECAM-1 and soluble CD40 ligand (sCD40L) levels were significantly higher in RA patients than in SLE and control groups. PECAM-1 polymorphisms in SLE were protective against atherosclerotic complications.en_US
dc.description.sponsorshipTrakya University Scientific Research Fund (TUBAP), Edirne, Turkeyen_US
dc.description.sponsorshipThis study was supported by the Trakya University Scientific Research Fund (TUBAP), Edirne, Turkey.en_US
dc.identifier.doi10.1007/s10067-014-2771-3
dc.identifier.endpage1743en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue12en_US
dc.identifier.pmid25201689en_US
dc.identifier.scopus2-s2.0-84925453990en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1737en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-014-2771-3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23067
dc.identifier.volume33en_US
dc.identifier.wosWOS:000345091900006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPECAM-1en_US
dc.subjectPolymorphismen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectScd40len_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectCell-Adhesion Molecule-1en_US
dc.subjectRevised Criteriaen_US
dc.subjectMechanismsen_US
dc.subjectExpressionen_US
dc.subjectSerumen_US
dc.subjectClassificationen_US
dc.subjectAssociationen_US
dc.subjectInfarctionen_US
dc.subjectCd40len_US
dc.subjectRisken_US
dc.titlePECAM-1 gene polymorphisms and soluble PECAM-1 level in rheumatoid arthritis and systemic lupus erythematosus patients: any link with clinical atherosclerotic events?en_US
dc.typeArticleen_US

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