Protective effects of the volatile oil of Nigella sativa seeds on ?-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorAktas, Cevat
dc.date.accessioned2024-06-12T11:09:13Z
dc.date.available2024-06-12T11:09:13Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the possible protective effects of the volatile oil of Nigella sativa (NS) seeds on insulin immunoreactivity and ultrastructural changes of pancreatic beta-cells in STZ-induced diabetic rats. STZ was injected intraperitoneally at a single dose of 50 mg/kg to induce diabetes. The rats in NS treated groups were given NS (0.2 ml/kg) once a day orally for 4 weeks starting 3 days prior to STZ injection. To date, no ultrastructural changes of pancreatic beta-cells in STZ induced diabetic rats by NS treatment have been reported. Islet cell degeneration and weak insulin immunohistochemical staining was observed in rats with STZ-induced diabetes. Increased intensity of staining for insulin, and preservation of beta-cell numbers were apparent in the NS-treated diabetic rats. The protective effect of NS on STZ-diabetic rats was evident by a moderate increase in the lowered secretory vesicles with granules and also slight destruction with loss of cristae within the mitochondria of beta-cell when compared to control rats. These findings suggest that NS treatment exerts a therapeutic protective effect in diabetes by decreasing morphological changes and preserving pancreatic beta-cell integrity. Consequently, NS may be clinically useful for protecting beta-cells against oxidative stress.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkey [855]en_US
dc.description.sponsorshipThis study was supported as Project 855 by Trakya University Research Center, Edirne, Turkey.en_US
dc.identifier.doi10.1007/s10735-009-9251-0
dc.identifier.endpage385en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue5-6en_US
dc.identifier.pmid20049514en_US
dc.identifier.scopus2-s2.0-77951023404en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-009-9251-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22726
dc.identifier.volume40en_US
dc.identifier.wosWOS:000275443300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNigella Sativaen_US
dc.subjectImmunoreactivityen_US
dc.subjectUltrastructureen_US
dc.subjectBeta-Cellen_US
dc.subjectExperimental Diabetesen_US
dc.subjectPoly(Adp-Ribose) Polymerase Geneen_US
dc.subjectPancreatic B-Cellsen_US
dc.subjectDna Strand Breaksen_US
dc.subjectOxidative Stressen_US
dc.subjectMiceen_US
dc.subjectThymoquinoneen_US
dc.subjectNicotinamideen_US
dc.subjectConstituenten_US
dc.subjectSynthetaseen_US
dc.subjectResistanten_US
dc.titleProtective effects of the volatile oil of Nigella sativa seeds on ?-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic studyen_US
dc.typeArticleen_US

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