Reduction of edema and infarction by memantine and MK-801 after focal cerebral ischaemia and reperfusion in rat

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dc.authorwosidIzgi, Ali Nail/AAD-6197-2020
dc.contributor.authorGörgülü, A
dc.contributor.authorKins, T
dc.contributor.authorÇobanoglu, S
dc.contributor.authorÜnal, F
dc.contributor.authorIzgi, N
dc.contributor.authorYanik, B
dc.contributor.authorKüçük, M
dc.date.accessioned2024-06-12T11:00:01Z
dc.date.available2024-06-12T11:00:01Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractN-methyl-D-aspartate (NMDA) receptor antagonists have been found to be protective after cerebral ischemia. However most of these drugs have limited value as neuroprotectives in clinical therapy because of their side effects. Memantine is a noncompetitive NMDA receptor antagonist and it has been used for the treatment of various cerebral disorders with relatively few side effects. We investigated the beneficial effects of Memantine and compared its effect with MK-801 in a temporary focal cerebral ischemia model. As cerebral ischemia model three hours middle cerebral artery occlusion (MCAO) with intraluminal thread and three hours reperfusion was used. 78 male Sprague-Dawley rats were divided into three groups as follows: Control (Saline), treatment 1 (MK-801), and treatment 2 (Memantine) groups. In the treated groups, 15 minutes after MCAO, MK-801 and Memantine were administered in amounts of 1 mg/kg and 10 mg/kg intraperitoneally respectively. After a 3 hour period of reperfusion, the animals were examined for neurological deficits and then killed. The following values were measured; cerebral water content, blood brain barrier (BBB) permeability at the core and periphery of the ischemic hemisphere and contralateral hemisphere and infarct volumes. The severity of neurological deficit (p < 0.001) and infarct volume (p < 0.001) was reduced in both Memantine and MK-801 treated groups compared with saline treated groups. Memantine attenuated brain edema formation and BBB permeability at the periphery (p < 0.01), MK-801 both at the core (p < 0.05) and the periphery (p < 0.01) of the ischemia. These results demonstrated that the NMDA receptor antagonists Memantine and MK-801 were neuroprotective when given 15 min after MCAO in temporary focal cerebral ischemia.en_US
dc.identifier.doi10.1007/s007010070027
dc.identifier.endpage1292en_US
dc.identifier.issn0001-6268
dc.identifier.issue11en_US
dc.identifier.pmid11201645en_US
dc.identifier.scopus2-s2.0-0034538373en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1287en_US
dc.identifier.urihttps://doi.org/10.1007/s007010070027
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20674
dc.identifier.volume142en_US
dc.identifier.wosWOS:000166115700027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Wienen_US
dc.relation.ispartofActa Neurochirurgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEdemaen_US
dc.subjectFocal Cerebral Ischemiaen_US
dc.subjectMemantineen_US
dc.subjectReperfusionen_US
dc.subjectMethyl-D-Aspartateen_US
dc.subjectBrain Edemaen_US
dc.subjectArtery Occlusionen_US
dc.subjectGlutamateen_US
dc.subjectAntagonisten_US
dc.subjectIschemiaen_US
dc.subjectAmantadineen_US
dc.subjectPotenten_US
dc.subjectDamageen_US
dc.subjectBlocken_US
dc.titleReduction of edema and infarction by memantine and MK-801 after focal cerebral ischaemia and reperfusion in raten_US
dc.typeArticleen_US

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