The Effects of L-Carnitine on Protein Oxidation of Streptozotocin-Induced Diabetic Rats

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dc.contributor.authorOzgun, Gulben Sayilan
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:59:25Z
dc.date.available2024-06-12T10:59:25Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt has been reported that there is a significant protein oxidation resulted from oxidative damage in patients with diabetes mellitus. The aim of this study is to investigate the effects of L-carnitine which has antioxidant activity on protein oxidation seen in diabetes. In the study, twenty adult male rats of Wistar strain were randomly divided into three groups as follows: control (n=5), diabetes (n=8) and L-carnitine+diabetes groups (n=7). Diabetes and L-carnitine+diabetes groups were intraperitonally injected with a single dose of 50 mg/kg streptozotocin prepared in the citrate buffer (pH 4.5). Control group was injected with only citrate buffer. 72 hours after the streptozotocin injection, L-carnitine was given intraperitonally (500 mg/kg/day) to L-carnitine+diabetes groups for 15 days. Physiological saline was given intraperitonally to other groups for 15 days. The levels of blood sugar (at 72 hours and 2(nd) week) and kidney tissue advanced oxidation protein products of diabetes and L-carnitine+diabetes groups were higher than those in control group (p<0.001, p<0.05 and p<0.01; respectively). Kidney protein carbonyl level of diabetes group was higher when compared with the control group and L-carnitine+diabetes group (p<0.01 for both). There was a significant positive correlation between kidney tissue total and protein thiol levels in all groups. As a result; we can report that L-carnitine partially prevents protein oxidation seen in diabetes mellitus.en_US
dc.identifier.endpage189en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-78349303409en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20439
dc.identifier.volume35en_US
dc.identifier.wosWOS:000282700000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectL-Carnitineen_US
dc.subjectProtein Oxidationen_US
dc.subjectDamage Parametersen_US
dc.subjectGlutathioneen_US
dc.subjectStressen_US
dc.subjectPlasmaen_US
dc.titleThe Effects of L-Carnitine on Protein Oxidation of Streptozotocin-Induced Diabetic Ratsen_US
dc.typeArticleen_US

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