Survivin expression, HPV positivity and microvessel density in oropharyngeal carcinomas and relationship with survival time

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dc.authoridTürkkan, Görkem/0000-0002-9084-2599
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109;
dc.authorwosidTürkkan, Görkem/E-7048-2017
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidTürkkan, Görkem/AAM-6705-2021
dc.contributor.authorTastekin, Ebru
dc.contributor.authorCaloglu, Vuslat Yurut
dc.contributor.authorDurankus, Nilufer Kilic
dc.contributor.authorSut, Necdet
dc.contributor.authorTurkkan, Gorkem
dc.contributor.authorCan, Nuray
dc.contributor.authorPuyan, Fulya Oz
dc.date.accessioned2024-06-12T11:11:44Z
dc.date.available2024-06-12T11:11:44Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Among head and neck cancers, those of the oral cavity and oropharynx are the second most prevalent following the larynx. This study aimed to research immunohistochemical expression of survivin, HPV positivity and microvessel density in tumors and their relationships with prognosis. Material and methods: Pathological materials and demographic properties of 46 patients were retrospectively evaluated. Survivin, HPV and CD34 (for microvessel density evaluation) antibodies were applied tumoral tissues. Survival times, clinical stage and differentiation were evaluated. Results: In univariate analysis, we observed that survivin, microvessel density and stage were significantly associated with survival time (p < 0.05). In multivariate analysis, only survivin and microvessel density were associated with survival time (p < 0.05). But we did not find significant correlation between neither tumor differentiation nor HPV positivity and survival (p > 0.05). Conclusions: Survivin levels and microvessel density were found to be effective prognostic factors and were related to survival in oral cavity and oropharyngeal cancers. Treatments targeting survivin expression and angiogenesis might be employed against these tumor groups.en_US
dc.identifier.doi10.5114/aoms.2015.56616
dc.identifier.endpage1473en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue6en_US
dc.identifier.pmid29181079en_US
dc.identifier.scopus2-s2.0-85032684601en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1467en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2015.56616
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22890
dc.identifier.volume13en_US
dc.identifier.wosWOS:000415133000026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOral Cavity Tumorsen_US
dc.subjectOropharyngeal Carcinomaen_US
dc.subjectPrognosisen_US
dc.subjectSurvivinen_US
dc.subjectSquamous-Cell Carcinomaen_US
dc.subjectHuman-Papillomavirus Infectionen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectOral-Canceren_US
dc.subjectPrognostic-Significanceen_US
dc.subjectBreast-Canceren_US
dc.subjectNeck-Canceren_US
dc.subjectAngiogenesisen_US
dc.subjectHeaden_US
dc.subjectMetastasisen_US
dc.titleSurvivin expression, HPV positivity and microvessel density in oropharyngeal carcinomas and relationship with survival timeen_US
dc.typeArticleen_US

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