Assessment of alterations in regional cerebral blood flow in patients with hypothyroidism due to Hashimoto's thyroiditis

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dc.authoridCermik, Tevfik Fikret/0000-0001-7622-7277
dc.authorwosidCermik, Tevfik Fikret/A-9694-2018
dc.contributor.authorKaya, M.
dc.contributor.authorCermik, T. F.
dc.contributor.authorBedel, D.
dc.contributor.authorKutucu, Y.
dc.contributor.authorTuglu, C.
dc.contributor.authorYigitbasi, Oe. N.
dc.date.accessioned2024-06-12T11:02:55Z
dc.date.available2024-06-12T11:02:55Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: The aim of this study was to assess regional cerebral blood flow (rCBF) using detailed semiquantative analysis of Tecnethium-99m hexamethylpropyleneamine (HMPAO) brain single-photon emission computered tomography (SPECT) in patients with hypothyroidism due to autoimmune thyroiditis. Patients, material and methods: Twenty patients (mean age: 42 +/- 9 yr) and 12 control subjects (mean age: 35.4 +/- 8.5 yr) were included in this study. The corticocerebellar rCBF ratios were obtained from 52 cerebral areas on 6 transaxial slices. By using control group rCBF ratios, lower reference values (RLV) (average ratio -2 SD) were calculated and the regions below RLV having an rCBF ratio were considered as abnormal decrease (hypoperfused) areas. Results: Significant reduced rCBF rates were measured for 15 (29%) cortical regions for the patient group. The areas in which significant reduced rCBF were demonstrated in the patient group were as follows: a) in the right hemisphere: superior frontal (slice 1 and 2), inferior frontal (slice 1), anterior temporal (slice 1 and 2), precentral gyrus (slice 1 and 2), postcentral gyrus (slice 1 and 2), and parietal cortex; b) in the left hemisphere: superior frontal (slice 1 and 2), inferior frontal (slice 1), caudate nucleus, and parietal cortex. The hypoperfusion was calculated in 154 (14%, 94 right and 60 left) cortical regions out of 1040 regions in the patient group. Conclusion: These findings indicate that the alteration of rCBF in patients with hypothyroidism due to Hashimoto's thyroiditis before T-4 therapy can be demonstrated with brain SPECT. Additionally, the degree of rCBF abnormalities could be determined with brain SPECT in patients with hypothyroidism due to Hashimoto's thyroiditis with or without neurologic or psychiatric symptoms.en_US
dc.identifier.doi10.1007/BF03346333
dc.identifier.endpage496en_US
dc.identifier.issn1720-8386
dc.identifier.issue6en_US
dc.identifier.pmid17646724en_US
dc.identifier.startpage491en_US
dc.identifier.urihttps://doi.org/10.1007/BF03346333
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21467
dc.identifier.volume30en_US
dc.identifier.wosWOS:000249405100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.subjectHypothyroidismen_US
dc.subjectCerebral Blood Flowen_US
dc.subjectTc-99m HMPACen_US
dc.subjectSPECTen_US
dc.subjectPositron-Emission-Tomographyen_US
dc.subjectTransient Hypothyroidismen_US
dc.subjectMajor Depressionen_US
dc.subjectAbnormalitiesen_US
dc.subjectBrainen_US
dc.subjectMetabolismen_US
dc.subjectDementiaen_US
dc.subjectDisorderen_US
dc.subjectAnxietyen_US
dc.subjectAnatomyen_US
dc.titleAssessment of alterations in regional cerebral blood flow in patients with hypothyroidism due to Hashimoto's thyroiditisen_US
dc.typeArticleen_US

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