The prevalence of activated protein C resistance and F V Leiden in healthy population of Edirne, Turkey

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dc.authorscopusid6504678141
dc.authorscopusid7003486028
dc.authorscopusid7004457653
dc.authorscopusid6701664192
dc.authorscopusid7004331288
dc.authorscopusid6602649806
dc.authorscopusid7103310507
dc.contributor.authorVurkun M.
dc.contributor.authorVural Ö.
dc.contributor.authorDemir M.
dc.contributor.authorTurgut B.
dc.contributor.authorGürgey A.
dc.contributor.authorParlak H.
dc.contributor.authorDuran N.
dc.date.accessioned2024-06-12T10:28:46Z
dc.date.available2024-06-12T10:28:46Z
dc.date.issued2002
dc.description.abstractActivated protein C (APC) resistance has been found to be an important cause of venous thrombosis. The prevalence of F V Leiden (FVL) in general population is variable according to the region and the ethnic group. The aim of this study was to determine the prevalence of APC resistance and FVL in healthy population in Edirne as a representative sample of province of Edirne. Total 467 healthy subjects were studied. There were 238 males (50.96%) and 229 females (49.04%). APC resistance was studied by functional and DNA methods. There were a total 22/476 subjects (4.7%) were APC resistance. There were 20/476 subjects (4.28%) who had FVL by DNA test. Of these, there were 18 heterozygous and 2 homozygous FVL and other two subjects have no FVL mutation but have the high levels of FVIII to explain acquired APC resistance. The coexistence of FVL and the deficiencies of protein C (1/22), protein S (2/22) and antithrombin (1/22) were also studied. No one of subjects had prothrombin gene mutation. The data showed that the prevalence of APC resistance and FVL in healthy Turkish population were similar to the previously reported publications in Turkey and Europe. One thing is a keeping in mind to be the coexistence of FVL and the other known thrombophilic risk factors.en_US
dc.identifier.endpage291en_US
dc.identifier.issn1300-7777
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0036403712en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage287en_US
dc.identifier.trdizinid19681en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/19681
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17413
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Haematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectActivated Protein C Resistance; Fv Leiden; Prevalence In Healthy Population; Turkeyen_US
dc.subjectActivated Protein C; Antithrombin; Blood Clotting Factor 5 Leiden; Dna; Protein S; Prothrombin; Activated Protein C Resistance; Adolescent; Adult; Aged; Article; Child; Ethnic Group; Europe; Female; Gene Mutation; Heterozygosity; Homozygosity; Human; Infant; Major Clinical Study; Male; Newborn; Prevalence; Protein C Deficiency; Risk Factor; Thrombophilia; Turkey (Republic); Vein Thrombosisen_US
dc.titleThe prevalence of activated protein C resistance and F V Leiden in healthy population of Edirne, Turkeyen_US
dc.typeArticleen_US

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