Value of technetium-99m diethyltriamine pentaaceticacid radioaerosol inhalation lung scintigraphy for the stage of amiodarone-induced pulmonary toxicity

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridSalihoglu, Yavuz Sami/0000-0003-2465-9128
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorDurmus-Altun, G
dc.contributor.authorAltun, A
dc.contributor.authorSalihoglu, YS
dc.contributor.authorAltaner, S
dc.contributor.authorBerkada, S
dc.contributor.authorOzbay, G
dc.date.accessioned2024-06-12T11:16:02Z
dc.date.available2024-06-12T11:16:02Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Amiodarone is a potent antiarrhythmic agent that is limited in clinical use by its adverse effects, including potentially life threatening amiodarone-induced pulmonary toxicity (AIPT). The alteration of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) radioaerosol lung clearance in AIPT was experimentally investigated. Methods: Eighteen white New Zealand rabbits (initial weight 4.1 +/- 0.2 kg) were divided into two groups. AIPT group (n = 13) was administered amiodarone (20 mg/kg BW) ip as a 5% aqueous solution for 6 week. The controls (n = 5) were administered the same amount of 0.9% saline ip. Four rabbits of AIPT group died due to AIPT. The reminders of AIPT group (n = 9) and controls underwent Tc-99rn DTPA radioaerosol lung scintigraphy at the end of the treatment period. AIPT group was divided into two subgroups according to histopathologic evaluation. AIPT-I had interstitial pneumonitis (n = 4) and AIPT-II had interstitial pneumonitis with fibrosis (n=5). Results: The mean T-1/2 values of in control, AIPT-I, and AIPT-II groups were found 54 +/- 4.4, 39.2 +/- 11.7 and 114.6 +/- 16.7 min, respectively. The mean T-1/2 values of Tc-99m DTPA significantly differ than other groups (chi(2) = 11.78, P=0.02). The significantly increased T-1/2 values was noted in AIPT-II group when compared with control (P=0.001). In contrast, AIPT-I group has significantly lower T-1/2 values than control group (P=0.03). Conclusion: We suggested that Tc-99m DTPA radioaerosol inhalation lung scintigraphy provides an accurate evaluation about stage of lung toxicity and therefore may be a useful tool for the monitoring of AIPT. (C) 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2003.07.006
dc.identifier.endpage197en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue2-3en_US
dc.identifier.pmid15193819en_US
dc.identifier.scopus2-s2.0-2942574807en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage193en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2003.07.006
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24174
dc.identifier.volume95en_US
dc.identifier.wosWOS:000222169900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTc-99m Diethyltriaminepentaaceticaciden_US
dc.subjectAmiodaroneen_US
dc.subjectPulmonary Toxicityen_US
dc.subjectSustained Ventricular-Tachycardiaen_US
dc.subjectEpithelial Permeabilityen_US
dc.subjectAerosolen_US
dc.subjectClearanceen_US
dc.subjectInjuryen_US
dc.titleValue of technetium-99m diethyltriamine pentaaceticacid radioaerosol inhalation lung scintigraphy for the stage of amiodarone-induced pulmonary toxicityen_US
dc.typeArticleen_US

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