Management of Differentiated Thyroid Cancer in the Presence of Resistance to Thyroid Hormone and TSH-Secreting Adenomas: A Report of Four Cases and Review of the Literature

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dc.authoridRefetoff, Samuel/0000-0003-0164-8231
dc.authoridSriphrapradang, Chutintorn/0000-0001-8294-8601
dc.authoridUnluturk, Ugur/0000-0002-5054-1396
dc.authorwosidRefetoff, Samuel/ABB-1263-2021
dc.authorwosidSriphrapradang, Chutintorn/AAG-8042-2019
dc.authorwosidERDOGAN, MURAT/JBJ-5779-2023
dc.authorwosidERDOGAN, MURAT/AAH-5455-2020
dc.authorwosidGullu, Sevim/AAH-4136-2020
dc.authorwosidemral, rıfat/AAH-1386-2020
dc.authorwosidUnluturk, Ugur/A-1988-2016
dc.contributor.authorUnluturk, Ugur
dc.contributor.authorSriphrapradang, Chutintorn
dc.contributor.authorErdogan, Murat Faik
dc.contributor.authorEmral, Rifat
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorRefetoff, Samuel
dc.contributor.authorGullu, Sevim
dc.date.accessioned2024-06-12T11:19:47Z
dc.date.available2024-06-12T11:19:47Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: An increased or normal serum TSH concentration, despite elevated thyroid hormone levels, is observed in resistance to thyroid hormone (RTH) and TSH-secreting adenomas (TSHomas). When coexistent with a differentiated thyroid cancer (DTC), maintenance of a suppression of TSH is challenging. Objectives: The aim of the study was to discuss the pitfalls arising from the failure to suppress TSH secretion in DTC and the strategies for proper treatment of DTC in association with RTH and TSHoma. Methods: Four unusual cases ofDTCassociated withTSHoma(2 cases), RTH(1 case), and an elevated TSH of unknown etiology (1 case) are presented, and the literature is reviewed. Results: Although a persistent mild TSH elevation may not be a risk factor for the development of DTC, it represents an important problem during the treatment of DTC. Aggressive treatment options should be applied in the proper order to prevent tumor recurrence and persistence in the absence of ideal TSH suppression. Conclusions: Although there is no agreed consensus regarding the management of DTC in the presence of persistent hyperthyrotropinemia, complete tumor removal followed by radioablation and attempts to reduce the serum TSH to the lowest tolerable level are recommended. The outcomes in the reported cases have not been unfavorable, despite the persistence of nonsuppressed TSH.en_US
dc.description.sponsorshipNational Institutes of Health [DK15070, RR04999]en_US
dc.description.sponsorshipThis work was supported in part by Grants DK15070 and RR04999 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health.en_US
dc.identifier.doi10.1210/jc.2012-4142
dc.identifier.endpage2217en_US
dc.identifier.issn0021-972X
dc.identifier.issn1945-7197
dc.identifier.issue6en_US
dc.identifier.pmid23553855en_US
dc.identifier.scopus2-s2.0-84878501365en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2210en_US
dc.identifier.urihttps://doi.org/10.1210/jc.2012-4142
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25341
dc.identifier.volume98en_US
dc.identifier.wosWOS:000319736500021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Press Incen_US
dc.relation.ispartofJournal Of Clinical Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectReceptor-Beta-Geneen_US
dc.subjectPituitary-Adenomaen_US
dc.subjectThyrotropin Suppressionen_US
dc.subjectCarcinomaen_US
dc.subjectPapillaryen_US
dc.subjectTherapyen_US
dc.subjectPatienten_US
dc.subjectMutationen_US
dc.subjectTumorsen_US
dc.subjectHyperthyroidismen_US
dc.titleManagement of Differentiated Thyroid Cancer in the Presence of Resistance to Thyroid Hormone and TSH-Secreting Adenomas: A Report of Four Cases and Review of the Literatureen_US
dc.typeReview Articleen_US

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