MAPK immunoreactivity in streptozotocin-induced diabetic rat testis

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dc.contributor.authorDonmez, Yeliz Bozdemir
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.date.accessioned2024-06-12T10:59:25Z
dc.date.available2024-06-12T10:59:25Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPURPOSE: To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes. METHODS: Twenty males Sprague-Dawley rats were randomly divided into a control group (n=8) and a diabetes group (administration of 40 mg/kg/day streptozotocin (STZ) for five sequential days, n=12). After six weeks, testicular biopsy samples were obtained for light microscopy and immunohistochemical methods. RESULTS: The PCNA (proliferating cell nuclear antigen) index was significantly decreased in the diabetes group (p=0.004) when compared to the control group. Both total (t)-ERK and phosphor (p)-ERK immunoreactivities were significantly decreased in the diabetes group (p=0.004, p<0.001, respectively). The t-JNK immunoreactivity was unchanged in both groups (p=0.125), while p-JNK immunoreactivity was significantly increased in the diabetic group (p=0.002). CONCLUSIONS: The decrease of androgen levels in the course of diabetes may contribute to the decrease of the immunoreactivities of t-ERK and p-ERK. JNK may be activated due to the changes in various cytokines and chemochines that participate in the oxidative stress process of diabetes. Therefore, testicular apoptosis may occur and lead to infertility associated with diabetes.en_US
dc.description.sponsorshipTrakya University Research Center [2008/116]en_US
dc.description.sponsorshipTrakya University Research Center (Project no : 2008/116)en_US
dc.identifier.doi10.1590/S0102-8650201400160004
dc.identifier.endpage650en_US
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue10en_US
dc.identifier.pmid25317996en_US
dc.identifier.scopus2-s2.0-84908075354en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage644en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-8650201400160004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20441
dc.identifier.volume29en_US
dc.identifier.wosWOS:000343982100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Cirurgica Brasileiraen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectMitogen-Activated Protein Kinasesen_US
dc.subjectExtracellular Signal-Regulated Kinasesen_US
dc.subjectJNK Mitogen-Activated Protein Kinasesen_US
dc.subjectStreptozocinen_US
dc.subjectTestesen_US
dc.subjectRatsen_US
dc.subjectTesticular Damageen_US
dc.subjectOxidative Stressen_US
dc.subjectSertoli-Cellsen_US
dc.subjectIn-Vitroen_US
dc.subjectApoptosisen_US
dc.subjectJnken_US
dc.subjectActivationen_US
dc.subjectIncreasesen_US
dc.subjectKinaseen_US
dc.subjectDeathen_US
dc.titleMAPK immunoreactivity in streptozotocin-induced diabetic rat testisen_US
dc.typeArticleen_US

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