Validation of a New Risk Score to Predict Contrast-Induced Nephropathy After Percutaneous Coronary Intervention

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridKonstantinides, Stavros/0000-0001-6359-7279
dc.authoridChalikias, George/0000-0003-4331-730X
dc.authoridGarcia-Moll, Xavier/0000-0001-7837-8378
dc.authoridMehmedbegovic, Zlatko/0000-0001-6400-1828
dc.authoridStankovic, Goran/0000-0002-9414-0885
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.authorwosidStakos, Dimitrios/AAO-8728-2021
dc.authorwosidKonstantinides, Stavros/AAL-3174-2021
dc.authorwosidChalikias, George/AAO-8148-2021
dc.authorwosidStankovic, Goran/Q-8507-2019
dc.contributor.authorTziakas, Dimittios
dc.contributor.authorChalikias, Georgios
dc.contributor.authorStakos, Dimitrios
dc.contributor.authorAltun, Armagan
dc.contributor.authorSivri, Nasir
dc.contributor.authorYetkin, Ertan
dc.contributor.authorGur, Mustafa
dc.date.accessioned2024-06-12T11:17:50Z
dc.date.available2024-06-12T11:17:50Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractContrast-induced nephropathy (CIN) is a frequent, potentially lethal complication of percutaneous coronary interventions (PCIs). We prospectively validated the diagnostic performance of a simple CIN risk score in a large multicenter international cohort of patients who underwent PCI. About 2,882 consecutive patients treated with elective or urgent PCI were enrolled. A simple CIN risk score was calculated for all patients by allocating points according to a prespecified scale (pre-existing renal disease = 2; metformin use = 2; previous PCI = 1; peripheral arterial disease = 2; and injected volume of contrast medium >= 300 ml = 1). CIN was defined as an increase, compared with baseline, of serum creatinine by >= 25%, or by >= 0.5 mg/dl, 48 hours after PCI. CIN occurred in 15.7% of the study population. The predictive accuracy of the CIN risk score was good (c-statistic 0.741, 95% confidence interval 0.713 to 0.769). Receiver-operating characteristic analysis identified a score of >= 3 as having the best diagnostic accuracy. Examination of the performance of the proposed risk score using different definitions of CIN yielded a robust predictive ability. The score exhibited good discrimination (area under the curve (>= 0.700) across all predefined subgroups of the study population. Compared with 2 previously published risk scores for CIN, our score demonstrated higher discriminative ability and resulted in a net reclassification improvement and an integrated discrimination improvement (p <0.001). In conclusion, the new risk score can easily be applied in the setting of urgent or elective PCI, allows for robust risk assessment and offers the potential to improve the peri-interventional management of patients at risk for CIN. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.amjcard.2014.02.004
dc.identifier.endpage1493en_US
dc.identifier.issn0002-9149
dc.identifier.issn1879-1913
dc.identifier.issue9en_US
dc.identifier.pmid24630389en_US
dc.identifier.scopus2-s2.0-84898667280en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1487en_US
dc.identifier.urihttps://doi.org/10.1016/j.amjcard.2014.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24868
dc.identifier.volume113en_US
dc.identifier.wosWOS:000335421700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherExcerpta Medica Inc-Elsevier Science Incen_US
dc.relation.ispartofAmerican Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClinical-Practice Guidelinesen_US
dc.subjectAcute-Renal-Failureen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectImpacten_US
dc.subjectAngioplastyen_US
dc.subjectDefinitionen_US
dc.subjectFrequencyen_US
dc.titleValidation of a New Risk Score to Predict Contrast-Induced Nephropathy After Percutaneous Coronary Interventionen_US
dc.typeArticleen_US

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