The effects of cardiopulmonary bypass on androgen hormones in coronary artery bypass surgery

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dc.authoridSunar, Hasan/0000-0002-1276-8549
dc.authoridCIKIRIKCIOGLU, MUSTAFA/0000-0003-1143-347X
dc.authorwosidSunar, Hasan/A-8685-2018
dc.authorwosidCanbaz, Sevgi/AAD-5192-2020
dc.contributor.authorCanbaz, S
dc.contributor.authorEge, T
dc.contributor.authorSunar, H
dc.contributor.authorCikirikcioglu, M
dc.contributor.authorAcipayam, M
dc.contributor.authorDuran, E
dc.date.accessioned2024-06-12T10:55:45Z
dc.date.available2024-06-12T10:55:45Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe effects of testosterone on coronary vasomotor regulation have been described by several recent reports. Here we investigated changes in serum androgen levels during and after cardiopulmonary bypass (CPB) in patients who had undergone coronary artery bypass surgery. Serum luteinizing hormone, free testosterone and dihydroepiandrestenedione sulphate (DHEA sulphate) levels were evaluated in 38 male coronary artery bypass surgery patients using a chemical immunoassay technique. All hormone levels were corrected to account for haemodilution. Serum-free testosterone level decreased significantly during weaning from CPB (from 15.7 +/- 4.2 nmol/l to 6.2 +/- 2.8 nmol/l), and an even greater decrease was observed in the first post-operative day (5.4 +/- 3.1 nmol/l). On the seventh post-operative day, free testosterone levels reached a normal value (11.8 +/- 5.5 nmol/l), although they were still significantly lower compared with the pre-operative value. There were slight alterations in serum DHEA sulphate levels, although the only significant decrease occurred from the first to the seventh day post-operation (from 4.7 +/- 2.2 pmol/l to 3.7 +/- 1.8 pmol/l, respectively). Serum luteinizing hormone levels were decreased during weaning from CPB (from 4.8 +/- 2.1 mIU/ml to 3.9 +/- 1.8 mIU/mI), but increased rapidly to the pre-operative value (5.5 +/- 2.5 mIU/ml) at the first post-operative day. These results show that CPB affects serum luteinizing hormone, free testosterone and dihydroepiandrestenedione sulphate levels. The free testosterone level decreases significantly both during and after CPB surgery.en_US
dc.identifier.doi10.1177/147323000203000102
dc.identifier.endpage14en_US
dc.identifier.issn0300-0605
dc.identifier.issue1en_US
dc.identifier.pmid11921506en_US
dc.identifier.scopus2-s2.0-0036269754en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1177/147323000203000102
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19542
dc.identifier.volume30en_US
dc.identifier.wosWOS:000174232500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Med Publen_US
dc.relation.ispartofJournal Of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiopulmonary Bypassen_US
dc.subjectAndrogenen_US
dc.subjectTestosteroneen_US
dc.subjectDihydroepiandrestenedione Sulphateen_US
dc.subjectLuteinizing Hormoneen_US
dc.subjectCardiac Surgeryen_US
dc.subjectHeart-Diseaseen_US
dc.subjectCardiac-Surgeryen_US
dc.subjectMyocardial-Ischemiaen_US
dc.subjectSex-Hormonesen_US
dc.subjectMenen_US
dc.subjectTestosteroneen_US
dc.subjectCortisolen_US
dc.titleThe effects of cardiopulmonary bypass on androgen hormones in coronary artery bypass surgeryen_US
dc.typeArticleen_US

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