The role of functional imaging in the diagnosis and management of late normal tissue injury
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Normal tissue injury after radiation therapy (RT) can be defined based on either clinical symptoms or laboratory/radiologic tests. In the research setting, functional imaging (eg, single-photon emission computed tomography [SPECT], positron-emission tomography [PET], and magnetic resonance imaging [MRI]) is useful because it provides objective quantitative data such as metabolic activity, perfusion, and soft-tissue contrast within tissues and organs. For RT-induced lung, heart, and parotid gland injury, pre- and post-RT SPECT images can be compared with the dose- and volume-dependent nature of regional injury. In the brain, SPECT can detect changes in perfusion and blood flow post-RT, and PET can detect metabolic changes, particularly to regions of the brain that have received doses above 40 to 50 Gy. On MRI, changes in contrast-enhanced images, T-1 and T-2 relaxation times, and pulmonary vascular resistance at different intervals pre- and post-RT show its ability to detect and distinguish different phases of radiation pneumonitis. Similarly, conventional and diffusion-weighted MRI can be used to differentiate between normal tissue edema, necrosis, and tumor in the irradiated brain, and magnetic resonance spectroscopy can measure changes in compounds, indicative of membrane and neuron disruption. The use of functional imaging is a powerful tool for early detection of RT-induced normal tissue injury, which may be related to long-term clinically significant injury.
Açıklama
7th International Conference on Dose, Time, and Fractionation in Radiation Oncology -- SEP 18-20, 2005 -- Madison, WI
Anahtar Kelimeler
Magnetic-Resonance-Spectroscopy, Acute Lymphoblastic-Leukemia, Radiation-Induced Changes, Breast-Cancer Patients, Dose-Volume Histogram, Malignant Brain-Tumors, Local Pulmonary Injury, Long-Term Survivors, Cell Lung-Cancer, Quality-Of-Life
Kaynak
Seminars In Radiation Oncology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
17
Sayı
2
