The Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiation

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dc.authoridHoyne, Gerard/0000-0002-7370-9139
dc.authoridYabas, Mehmet/0000-0002-3462-5389
dc.authorwosidHoyne, Gerard/M-5406-2013
dc.authorwosidYabas, Mehmet/D-9513-2012
dc.contributor.authorYabas, Mehmet
dc.contributor.authorElliott, Hannah
dc.contributor.authorHoyne, Gerard F.
dc.date.accessioned2024-06-12T10:52:20Z
dc.date.available2024-06-12T10:52:20Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAlternative splicing of pre-mRNA helps to enhance the genetic diversity within mammalian cells by increasing the number of protein isoforms that can be generated from one gene product. This provides a great deal of flexibility to the host cell to alter protein function, but when dysregulation in splicing occurs this can have important impact on health and disease. Alternative splicing is widely used in the mammalian immune system to control the development and function of antigen specific lymphocytes. In this review we will examine the splicing of pre-mRNAs yielding key proteins in the immune system that regulate apoptosis, lymphocyte differentiation, activation and homeostasis, and discuss how defects in splicing can contribute to diseases. We will describe how disruption to trans-acting factors, such as heterogeneous nuclear ribonucleoproteins (hnRNPs), can impact on cell survival and differentiation in the immune system.en_US
dc.description.sponsorshipJuvenile Diabetes Research Foundation [4-2006-1025]; Diabetes Research Foundation of Western Australia; Ministry of National Education, Republic of Turkeyen_US
dc.description.sponsorshipWe would like to acknowledge grant support for these studies from the Juvenile Diabetes Research Foundation (4-2006-1025) and Diabetes Research Foundation of Western Australia awarded to Gerard F. Hoyne. Mehmet Yabas was supported by a postgraduate award from the Ministry of National Education, Republic of Turkey.en_US
dc.identifier.doi10.3390/ijms17010003
dc.identifier.issn1422-0067
dc.identifier.issue1en_US
dc.identifier.pmid26703587en_US
dc.identifier.scopus2-s2.0-84951788802en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ijms17010003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18678
dc.identifier.volume17en_US
dc.identifier.wosWOS:000374583800003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofInternational Journal Of Molecular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectB Cellsen_US
dc.subjectT Cellsen_US
dc.subjectHnrnp Proteinsen_US
dc.subjectImmune Toleranceen_US
dc.subjectPre-Mrna Alternative Splicingen_US
dc.subjectPre-Messenger-Rnaen_US
dc.subjectB-Cellen_US
dc.subjectElongation-Factoren_US
dc.subjectPolymerase-Iien_US
dc.subjectCd45 Isoformsen_US
dc.subjectT-Cellsen_US
dc.subjectHnrnp-Len_US
dc.subjectTyrosine Phosphataseen_US
dc.subjectSignaling Thresholdsen_US
dc.subjectDependent Regulationen_US
dc.titleThe Role of Alternative Splicing in the Control of Immune Homeostasis and Cellular Differentiationen_US
dc.typeReview Articleen_US

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