Hemodynamic effects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs after exercise

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dc.authoridPalabıyık, Orkide/0000-0002-3488-3740
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorVardar, Selma Arzu
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorGurel, Elif Ezgi
dc.contributor.authorCaliskan, Semra
dc.contributor.authorTopcu Ozen, Serap
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:52:50Z
dc.date.available2024-06-12T10:52:50Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes. We compared the hemodynamic effects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed by reperfusion in exercised rat hearts with nonexercised ones. Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups after a running protocol for 5 days and 4 nonexercised (NE) groups. In the first protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the second protocol, different doses of isatin (0.1, 10, 100 mu M/L) were added to the perfusion solution before ANP in 3 E and 3 NE groups. Left ventricular developed pressure (LVDP) and maximum and minimum rates of change in left ventricular pressure (dP/dtmax and dP/dtmin) were recorded. Results: Higher LVDP and dP/dtmin values were observed in the E group than the NE group following addition of ANP before ischemia. Values of dP/dtmax were higher in the E group at the first minute of reperfusion period. Hemodynamic difference was not observed between groups given the same amount of isatin before ANP. Conclusion: This study indicated that higher ANP concentrations before ischemia were more effective on the left ventricle contractility and relaxation functions in the hearts that were exposed to exercise.en_US
dc.description.sponsorshipTrakya University Research Funden_US
dc.description.sponsorshipThis study was supported by a grant from the Trakya University Research Fund.en_US
dc.identifier.doi10.3906/sag-1307-42
dc.identifier.endpage305en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid26084118en_US
dc.identifier.scopus2-s2.0-84926360438en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage298en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1307-42
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18851
dc.identifier.volume45en_US
dc.identifier.wosWOS:000352482000007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtrial Natriuretic Peptideen_US
dc.subjectIschemiaen_US
dc.subjectExerciseen_US
dc.subjectCardiac Contractilityen_US
dc.subjectIsatinen_US
dc.subjectInfarctionen_US
dc.subjectToleranceen_US
dc.subjectResponsesen_US
dc.subjectProtectsen_US
dc.subjectHearten_US
dc.titleHemodynamic effects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs after exerciseen_US
dc.typeArticleen_US

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