Cervical lymphadenitis: tuberculosis or tularaemia?

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dc.authoridKarabay, Oguz/0000-0003-1514-1685
dc.authoridGurcan, Saban/0000-0002-5052-481X
dc.authoridKarabay, Oguz/0000-0003-0502-432X
dc.authorwosidKarabay, Oguz/HHN-5893-2022
dc.authorwosidkaradenizli, aynur/G-2897-2018
dc.authorwosidGurcan, Saban/D-2754-2017
dc.contributor.authorKarabay, O.
dc.contributor.authorKilic, S.
dc.contributor.authorGurcan, S.
dc.contributor.authorPelitli, T.
dc.contributor.authorKaradenizli, A.
dc.contributor.authorBozkurt, H.
dc.contributor.authorBostanci, S.
dc.date.accessioned2024-06-12T10:56:05Z
dc.date.available2024-06-12T10:56:05Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBoth tuberculosis cervical lymphadenitis (TCL) and oropharyngeal tularaemia (OT) have similar signs, symptoms and pathological findings. We aimed to investigate the frequency of tularaemia antibodies in patients diagnosed with TCL. Using data from the Tuberculosis Control Dispensaries between the years of 2008 and 2011 in Turkey, all patients diagnosed with TCL were informed about and included in the study. Control group subjects were selected from healthy blood donors who lived in the same region. After informed consent was obtained, the sera obtained from volunteer TCL patients and the control group were tested with a microagglutination technique for Francisella tularensis. Antibodies to Brucella were also investigated with a tube agglutination test for cross-reactivity in sera that were seropositive for tularaemia. Sera were obtained from a total of 1170 individuals in the TCL group and 596 in the control group from 67 of 81 provinces in Turkey. Francisella tularensis-positive antibodies were found in 79 (6.75%) cases in the TCL group and two (0.33%) cases in the control group with a titre of 1:80 (p<0.01). When the presence of antibody of any titre was considered, the ratio became 8.2% (96/1170) in the TCL group and 0.67% (4/596) in the control group (p<0.001). For the first time, with this study, tularaemia serology was found to be positive in a significant portion (6.75%) of diagnosed cases of TCL. In tularaemia endemic regions, it was concluded that tularaemia serology should be investigated in patients suspected of having TCL.en_US
dc.description.sponsorshipTurkish Ministry of Healthen_US
dc.description.sponsorshipThis project was funded by the Turkish Ministry of Health. We would like to thank Prof. Dr Recep AKDAG.en_US
dc.identifier.doi10.1111/1469-0691.12097
dc.identifier.endpageE117en_US
dc.identifier.issn1198-743X
dc.identifier.issn1469-0691
dc.identifier.issue2en_US
dc.identifier.pmid23211027en_US
dc.identifier.scopus2-s2.0-84873524526en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE113en_US
dc.identifier.urihttps://doi.org/10.1111/1469-0691.12097
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19668
dc.identifier.volume19en_US
dc.identifier.wosWOS:000314656100009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofClinical Microbiology And Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCervical Lymphadenitisen_US
dc.subjectFrancisella Tularensisen_US
dc.subjectLymphadenitisen_US
dc.subjectOropharyngeal Tularaemiaen_US
dc.subjectTuberculosisen_US
dc.subjectMicroagglutination Testen_US
dc.subjectLymph-Node Tuberculosisen_US
dc.subjectDiagnosisen_US
dc.subjectTurkeyen_US
dc.titleCervical lymphadenitis: tuberculosis or tularaemia?en_US
dc.typeArticleen_US

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