EFFICACY OF COLISTIN AND NON-COLISTIN MONOTHERAPIES IN MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII BACTEREMIA/SEPSIS

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dc.authoridKarahocagil, Mustafa Kasım/0000-0002-5171-7306
dc.authoridDurdu, Bulent/0000-0002-0244-4006
dc.authoridbalkan, ilker inanc/0000-0002-8977-5931
dc.authoridCESUR, SALİH/0000-0003-4960-7375
dc.authoridKarabay, Oguz/0000-0003-1514-1685
dc.authoridSezak, Nurbanu/0000-0001-9472-1340
dc.authoridAlp Meşe, Emine/0000-0003-0189-6008
dc.authorwosidKarahocagil, Mustafa Kasım/JVZ-6523-2024
dc.authorwosidDurdu, Bulent/I-7851-2016
dc.authorwosidHosoglu, Salih/AGH-2653-2022
dc.authorwosidbalkan, ilker inanc/AAI-1578-2019
dc.authorwosidKilic, Aysegul Ulu/AAM-1069-2021
dc.authorwosidARSLAN, FERHAT/ABG-5757-2021
dc.authorwosidCESUR, SALİH/AGW-4011-2022
dc.contributor.authorKarabay, Oguz
dc.contributor.authorBatirel, Ayse
dc.contributor.authorBalkan, Ilker Inanc
dc.contributor.authorAgalar, Canan
dc.contributor.authorAkalin, Serife
dc.contributor.authorAlici, Ozlem
dc.contributor.authorAlp, Emine
dc.date.accessioned2024-06-12T10:50:23Z
dc.date.available2024-06-12T10:50:23Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: This retrospective study aimed to investigate the efficacies of colistin and non-colistin monotherapies in multi-drug resistant Acinetobacter baumannii bacteremia (MDR-AB). Materials and methods: Cases with MDR-AB from 27 tertiary-referral hospitals between January 2009 and December 2012 were included. Patients' data that were on either colistin monotherapy (CM) or non-colistin monotherapy (NCM) were compared. Mortality on Day 14 was the primary endpoint, whereas microbiological eradication and clinical outcome were the secondary ones. Results: Eighty-four cases were included in the study with 36 being in the CM group and 48 in the NCM group. Thirty-eight (452%) cases were male and the mean age was 602 years. The mean durations of pre-MDR-AB hospital stay and intensive care unit stay were 25.8 days and 20.9 days, respectively. All of the cases had fever (>38 degrees C). The mean Pitt bacteremia score (PBS) of the patients was calculated as 6.8, APACHE 2 score as 18.9 and the Charlson co-morbidity index (CCI) as 3.7 (CM: 3.6 vs. NCM: 3.9). Twenty (55.6%) cases in the CM group and 26 cases in the NCM group (542%) (p=0.81) died; 9 cases in the CM group (25%) and 16 cases in the NCM group (33 3%) had treatment failure (P=0.55). Bacteriological eradication was achieved in 20 (55.6%) cases in the CM group and in 36 cases (75%) in the NCM group (P=0.061). Conclusions: No significant difference could be identified between the colistin monotherapy and non-colistin monotherapy options in MDR-AB cases with respect to the results of efficacy and 14-day mortality.en_US
dc.identifier.endpage1143en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue5en_US
dc.identifier.startpage1137en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17985
dc.identifier.volume30en_US
dc.identifier.wosWOS:000364114800027en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcinetobacter Baumanniien_US
dc.subjectBacteremiaen_US
dc.subjectColistinen_US
dc.subjectMonotherapyen_US
dc.subjectMulti-Drug Resistanten_US
dc.subjectSepsisen_US
dc.subjectCombination Therapyen_US
dc.subjectClinical Impacten_US
dc.subjectRisk-Factorsen_US
dc.subjectInfectionsen_US
dc.subjectAmpicillinen_US
dc.subjectSulbactamen_US
dc.subjectEmergenceen_US
dc.subjectVs.en_US
dc.titleEFFICACY OF COLISTIN AND NON-COLISTIN MONOTHERAPIES IN MULTI-DRUG RESISTANT ACINETOBACTER BAUMANNII BACTEREMIA/SEPSISen_US
dc.typeArticleen_US

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