The Incidence of Venous Thromboembolism and Impact on Survival in Hodgkin Lymphoma

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dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authoridAlp Kirkizlar, Tugcan/0000-0002-1361-6213
dc.authoridDemirci, Ufuk/0000-0001-6923-1470
dc.authoridASKER, ISMAIL/0000-0002-4528-7194
dc.authorwosidAlp Kirkizlar, Tugcan/HMD-4249-2023
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.authorwosidAlp Kirkizlar, Tugcan/AAI-5246-2020
dc.contributor.authorKirkizlar, Onur
dc.contributor.authorKirkizlar, Tugcan Alp
dc.contributor.authorUmit, Elif Gulsum
dc.contributor.authorAsker, Ismail
dc.contributor.authorBaysal, Mehmet
dc.contributor.authorBas, Volkan
dc.contributor.authorGulsaran, Sedanur Karaman
dc.date.accessioned2024-06-12T11:07:23Z
dc.date.available2024-06-12T11:07:23Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractVenous thromboembolic events are associated with high morbidity and mortality in malignancy patients. We should be aware in terms of venous thromboembolism in patients who have involvement of spleen, advanced stage disease, or a central venous line, especially initial high fibrinogen levels, even with a good performance status. Background: Thrombosis increase the acute and long-term morbidity and mortality in malignancy patients. We analyzed venous thromboembolism (VTE) in patients with Hodgkin lymphoma, the impact of VTE on survival, predisposing factors for VTE, and predicting value of Khorana and ThroLy score models. Patients and Methods: We included 150 adult patients with Hodgkin lymphoma between January 2010 and 2018 at our university hospital. Results: VTE was observed in 31 patients (20.7%). The types of VTE were 18 upper and 3 lower extremity deep vein thrombosis and 10 pulmonary embolism (1 with lower extremity deep vein thrombosis). Twenty-nine patients developed VTE during the treatment with a median time of episode as 5 months. In logistic regression analysis, a body mass index of >32 kg/m(2), high fibrinogen levels, initial thrombocytosis and leukocytosis, splenic and extranodal involvement, presence of a central venous line, advanced stage, line of treatment status of thromboprophylaxis, VTE timing, and better Eastern Cooperative Oncology Group performance scores were observed to be related with VTE. Kaplan Meier survival analysis showed a negative impact of VTE on survival. Khorana and ThroLy risk assessment models were found predictive for VTE (P = .000 and P = .003, respectively), although only ThroLy score was associated with the survival. Conclusion: Thromboprophylaxis and precautions for VTE in patients with Hodgkin lymphoma according to validated risk assessment models can improve prognosis and quality of life owing to the impact of VTE on survival in the study. (C) 2020 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.clml.2020.02.021
dc.identifier.endpage547en_US
dc.identifier.issn2152-2650
dc.identifier.issn2152-2669
dc.identifier.issue8en_US
dc.identifier.pmid32245743en_US
dc.identifier.scopus2-s2.0-85082829150en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage542en_US
dc.identifier.urihttps://doi.org/10.1016/j.clml.2020.02.021
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22013
dc.identifier.volume20en_US
dc.identifier.wosWOS:000552071100019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCig Media Group, Lpen_US
dc.relation.ispartofClinical Lymphoma Myeloma & Leukemiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKhoranaen_US
dc.subjectMortalityen_US
dc.subjectRisk Factorsen_US
dc.subjectThrolyen_US
dc.subjectThrombosisen_US
dc.subjectDeep-Vein Thrombosisen_US
dc.subjectCancer-Patientsen_US
dc.subjectKhorana Scoreen_US
dc.subjectRisk-Factorsen_US
dc.subjectOutcomes Validationen_US
dc.subjectPredictive Modelen_US
dc.subjectChemotherapyen_US
dc.subjectChildrenen_US
dc.subjectCatheteren_US
dc.subjectEmbolismen_US
dc.titleThe Incidence of Venous Thromboembolism and Impact on Survival in Hodgkin Lymphomaen_US
dc.typeArticleen_US

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