Noninvasive Models to Predict Liver Fibrosis in Patients with Chronic Hepatitis B: A Study from Turkey

Basit Öğe Kaydı
dc.authoridBekçibaşı, Muhammed/0000-0003-0230-9127
dc.authoridBestepe Dursun, Zehra/0000-0002-6736-0380
dc.authoridÇelik, İlhami/0000-0002-2604-3776
dc.authoridErtem, Gunay/0000-0001-8760-0030
dc.authoridYardimci, Ahmet Cem/0000-0002-4727-3239
dc.authoridBekçibaşı, Muhammed/0000-0003-0230-9127
dc.authoridBarut, Sener/0000-0003-2047-8573
dc.authorwosidBekçibaşı, Muhammed/AAO-9658-2021
dc.authorwosidBestepe Dursun, Zehra/GQH-2972-2022
dc.authorwosidAKENGİN ÖCAL, GÜLFEM/JNS-4435-2023
dc.authorwosidÇelik, İlhami/D-1702-2017
dc.authorwosidErtem, Gunay/GRJ-7397-2022
dc.authorwosidYardimci, Ahmet Cem/AAQ-8148-2021
dc.authorwosidYılmaz Karadağ, Fatma/ABC-1574-2021
dc.contributor.authorKorkmaz, Pinar
dc.contributor.authorDemirturk, Nese
dc.contributor.authorBatirel, Ayse
dc.contributor.authorYardimci, Ahmet Cem
dc.contributor.authorCagir, Unal
dc.contributor.authorNemli, Salih Atakan
dc.contributor.authorKorkmaz, Fatime
dc.date.accessioned2024-06-12T10:56:25Z
dc.date.available2024-06-12T10:56:25Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Manynoninvasive methods, including aspartateaminotransaminase (AST)/alanineaminotransaminase (ALT) ratio (AAR), AST-to-platelet ratio index (APRI), Bonacini cirrhosis discriminant score (CDS), fibrosis-4 (FIB4) index, and age-platelet index (API), have been described to determine the stage of hepatic fibrosis. However, thesemethodsare developed for patients with chronic hepatitisC(CHC) andproduce conflicting results in the prediction of liver fibrosis in patients with chronic hepatitis B (CHB). Objectives: The aim of this study was to evaluate the relationship between 7 noninvasive models, including AAR, APRI, CDS, API, FIB-4, neutrophil-to-lymphocyte ratio (NLR), and red cell distribution width (RDW)-to-platelet ratio (RPR) in patients with CHB. Methods: The study population included all patients with CHB, undergoing liver biopsy to determine HBsAg and HBV DNA positivity in more than 6 months. Results: A total of 2520 treatment-naive CHB patients from 40 different centers were included in the study. In total, 62.6% of the patients were male, and the mean age was 40.60 +/- 12.34 years (minimum, 18 years; maximum, 77 years). The Ishak fibrosis score was >= 3 in 29.8% of the patients, indicating significant fibrosis. The mean API, APRI, CDS, NLR, FIB4, and RPR scores in the noninvasive models were significantly different between the groups with significant and low fibrosis (P < 0.05). All the noninvave models (API, APRI, AAR, CDS, NLR, RPR, and FIB4) were found to be significant in the discrimination of cirrhosis (P < 0.05). In the multiple logistic regression analysis, CDS, albumin, alkaline phosphatase (ALP), total bilirubin, neutrophil count, NLR, mean platelet volume (MPV), and FIB4 were independent indices for cirrhosis. Conclusions: In the present study, the role of noninvasive tests in the prediction of liver fibrosis stage and cirrhosis was evaluated in a large cohort of CHB patients. Overall, noninvasive models are gradually becoming more promising. Accordingly, the need for liver biopsy can be reduced with a combination of noninvasive methods in the future.en_US
dc.identifier.doi10.5812/hepatmon.60266
dc.identifier.issn1735-143X
dc.identifier.issn1735-3408
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85042031971en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.5812/hepatmon.60266
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19784
dc.identifier.volume17en_US
dc.identifier.wosWOS:000429311600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKowsar Publen_US
dc.relation.ispartofHepatitis Monthlyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Hepatitis Ben_US
dc.subjectLiveren_US
dc.subjectFibrosisen_US
dc.subjectNoninvasive Modelsen_US
dc.subjectPlatelet Ratio Indexen_US
dc.subjectC Virus-Infectionen_US
dc.subjectLymphocyte Ratioen_US
dc.subjectCirrhosisen_US
dc.subjectNeutrophilen_US
dc.subjectBiopsyen_US
dc.subjectManagementen_US
dc.subjectCohorten_US
dc.subjectTestsen_US
dc.titleNoninvasive Models to Predict Liver Fibrosis in Patients with Chronic Hepatitis B: A Study from Turkeyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu