The importance of pretreatment performance status and LDH level in patients with stage III-IV nasopharyngeal carcinoma

Basit Öğe Kaydı
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorCaloglu, Murat
dc.contributor.authorKaragol, Hakan
dc.contributor.authorCosar-Alas, Rusen
dc.contributor.authorKocak, Zafer
dc.date.accessioned2024-06-12T11:07:31Z
dc.date.available2024-06-12T11:07:31Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVES To evaluate the prognostic factors in patients treated with radiotherapy for locally advanced nasopharyngeal carcinoma. METHODS Forty-eight patients (37 males, 11 females) treated between September 1999 and September 2007 were assessed retrospectively. RESULTS Ten patients (21%) recurred loco-regionally. Gender (p=0.022), Eastern Cooperative Oncology Group (ECOG) performance status (PS) (p<0.0001), hemoglobin (Hb) (p=0.0035), and lactate dehydrogenase (LDH) (p=0.032) were prognostic for loco-regional control. On multivariate analysis, only PS (p<0.003) remained significant. Eighteen (38%) patients had distant metastases. On univariate analysis, PS (p=0.022), Hb (p=0.002), alkaline phosphatase (ALP) (p=0.004), LDH (p=0.007), and completion of radiotherapy (p=0.014) were prognostic for distant metastasis. On Cox regression analysis, only LDH (p=0.001) remained significant. There were 27 deaths at the time of analysis. On logrank analysis, PS (p=0.012), completion of radiotherapy (p<0.0001), metastasis (p=0.018), and LDH (p=0.018) were prognostic for overall survival. On Cox regression analysis, only LDH (p=0.026) remained significant. CONCLUSION The pre-treatment LDH was prognostic for distant metastasis and overall survival while PS was prognostic for loco-regional control.en_US
dc.identifier.endpage72en_US
dc.identifier.issn1300-7467
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-77954577240en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage65en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22075
dc.identifier.volume24en_US
dc.identifier.wosWOS:000439262300002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLDH Levelen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectPerformance Statusen_US
dc.subjectRadiotherapyen_US
dc.titleThe importance of pretreatment performance status and LDH level in patients with stage III-IV nasopharyngeal carcinomaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu