Evaluation of in vitro Antioxidant, Antimicrobial and Cytotoxic Activities of Crude Ethanol Extract and Fractions of Achillea sintenisii Hub. Mor.

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dc.authorid, Nuraniye/0000-0002-4674-7009
dc.authoridCevik, Ozge/0000-0002-9325-3757
dc.authoridAtas, Mehmet/0000-0002-9425-0080
dc.authorwosidCevik, Ozge/F-1326-2014
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAtas, Mehmet
dc.contributor.authorTekin, Mehmet
dc.contributor.authorCevik, Ozge
dc.date.accessioned2024-06-12T10:50:22Z
dc.date.available2024-06-12T10:50:22Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The Achillea species have been used to treat various ailments due to its anti-inflammatory, hemostatic, spasmolytic and cholagogue effects in the Turkish traditional medicine. However, there is no biological activity studies on some Achillea species except for the well-knowns. This work aimed to determine the antioxidant, antimicrobial and cytotoxic activities of the crude ethanolic extracts and fractions of Achillea sintenisii using in vitro methods. Methods: The antioxidant activity was investigated by DPPH (1,1'-diphenyl - 2-picrylhydrazyl), ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging, total phenol and total flavonoid content, and iron chelating methods. Antimicrobial activity evaluated by micro-plate dilution method against five test organisms. Cytotoxicity was determined by MTT method using MCF-7 breast cancer cell line and PC-3 prostate cancer cell line. Apoptosis was also measured by AO/EB staining. Results: The n-Hexane fractions showed the highest antimicrobial and cytotoxic activities, respectively. Administration of the extracts on the cancer cells showed a concentration dependent inhibition on cell proliferation. The anti-proliferation effect could be via apoptosis and associated with the cell death. Conclusion: The results showed that the extracts demonstrated antioxidant, antimicrobial, and cytotoxic activity, also supports the claims of traditional usage.en_US
dc.description.sponsorshipSivas Cumhuriyet University Academic Research Grants [CUBAP ECZ-020]en_US
dc.description.sponsorshipThis work was supported by the Sivas Cumhuriyet University Academic Research Grants (Grant number: CUBAP ECZ-020).en_US
dc.identifier.doi10.33808/clinexphealthsci.1058614
dc.identifier.endpage524en_US
dc.identifier.issn2459-1459
dc.identifier.issue3en_US
dc.identifier.startpage517en_US
dc.identifier.trdizinid1196401en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.1058614
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1196401
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17980
dc.identifier.volume13en_US
dc.identifier.wosWOS:001153376600011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical And Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAchillea Sintenisiien_US
dc.subjectAntioxidanten_US
dc.subjectMicrodilutionen_US
dc.subjectCytotoxicityen_US
dc.subjectKoch Essential Oilen_US
dc.subjectChemical-Compositionen_US
dc.subjectBiological-Activitiesen_US
dc.subjectMethanol Extractsen_US
dc.subjectL.en_US
dc.subjectTeretifoliaen_US
dc.subjectAnticholinesteraseen_US
dc.subjectConstituentsen_US
dc.subjectMillefoliumen_US
dc.subjectLycaonicaen_US
dc.titleEvaluation of in vitro Antioxidant, Antimicrobial and Cytotoxic Activities of Crude Ethanol Extract and Fractions of Achillea sintenisii Hub. Mor.en_US
dc.typeArticleen_US

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