Is the Charlson Comorbidity Index a Prognostic Indicator for Toxicity and Mortality in Elderly Patients with Locally Advanced Rectal Cancer?

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dc.authoridKöstek, Osman/0000-0002-1901-5603
dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.authoridDemircan, Nazim/0000-0001-6630-5278
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authorwosidKöstek, Osman/AAA-3604-2019
dc.authorwosidHacioglu, Bekir/GZH-1824-2022
dc.authorwosidDemircan, Nazim/HHY-8715-2022
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.authorwosidZengin, Nurullah/KBQ-0049-2024
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.contributor.authorKostek, Osman
dc.contributor.authorBozkaya, Yakup
dc.contributor.authorHacioglu, Muhammet Bekir
dc.contributor.authorOzdemir, Nuriye Yildirim
dc.contributor.authorYilmaz, Erdem
dc.contributor.authorDemircan, Nazim Can
dc.contributor.authorErdogan, Bulent
dc.date.accessioned2024-06-12T10:56:13Z
dc.date.available2024-06-12T10:56:13Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Aging is significantly related to multiple comorbidities. Even with a good performance score, some elderly patients may have poor survival outcomes. We aimed to evaluate the prognostic value of the Charlson comorbidity index (CCI) for mortality and toxicity in elderly patients with locally advanced rectal cancer (LARC). Methods: Seventy-two elderly patients with LARC who were treated with neoadjuvant chemoradiotherapy (CRT) were included. Based on their CCI score, severity of the comorbidity was categorized into 2 groups: CCI<7 and CCI >= 7. Results: The overall survival (OS) at 5 years was 54.4 percent in patients treated with neoadjuvant CRT. Median OS was not reached for all patients as well as patients with CCI score <7, but median OS was 25 (95% CI 1.0-62.1) months in patients with CCI >= 7 (P=0.002). The OS at 2 years was 79.1 percent in the patients with CCI <7 and 50.0 percent in the patients with CCI score >= 7 (P=0.002). Moreover, there was a trend toward, patients with higher CCI score who had more treatment related to grade 3 or 4 toxicity compared to those with CCI score <7 (33.3% vs 13.3%, respectively, P=0.09). Multivariable analysis indicated that the CCI score=7, presence of down-staging after therapy and clinical stage (III) independently predict mortality (HR 6.14, 95% CI 2.45-15.35, P<0.001) in patients with LARC. Conclusion: Although CCI score was not significantly associated with both toxicity and disease-free survival (DFS), we suggest that baseline CCI score might be a valuable prognostic indicator for physicians to evaluate elderly patiens with LARC for optimal treatment.en_US
dc.identifier.endpage241en_US
dc.identifier.issn1029-2977
dc.identifier.issn1735-3947
dc.identifier.issue5en_US
dc.identifier.pmid31256595en_US
dc.identifier.startpage236en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19690
dc.identifier.volume22en_US
dc.identifier.wosWOS:000471761700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcad Medical Sciences I R Iranen_US
dc.relation.ispartofArchives Of Iranian Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCharlson Comorbidity Indexen_US
dc.subjectElderly Patientsen_US
dc.subjectLocally Advanced Rectal Canceren_US
dc.subjectMortalityen_US
dc.subjectToxicityen_US
dc.subjectColon-Canceren_US
dc.subjectChemoradiotherapyen_US
dc.subjectNeeden_US
dc.titleIs the Charlson Comorbidity Index a Prognostic Indicator for Toxicity and Mortality in Elderly Patients with Locally Advanced Rectal Cancer?en_US
dc.typeArticleen_US

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