Response rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohort

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dc.authoridKaradag, Omer/0000-0002-3443-3117
dc.authoridYazıcı, Ayten/0000-0003-2167-4509
dc.authoridAkkoc, Nurullah/0000-0002-3718-171X
dc.authoridAksu, Kenan/0000-0001-8889-2688
dc.authoridALIBAZ-ONER, FATMA/0000-0002-6653-1758
dc.authoridkucuksahin, orhan/0000-0003-4530-2304
dc.authoridKaradag, Omer/0000-0002-3443-3117
dc.authorwosidKeser, Gokhan/I-4282-2019
dc.authorwosidKaradag, Omer/AAR-4219-2020
dc.authorwosidKimyon, Gezmiş/AAY-4798-2020
dc.authorwosiderten, sukran/IZE-6133-2023
dc.authorwosidErtenli, Ihsan/AAV-7175-2021
dc.authorwosidYazıcı, Ayten/AAT-3636-2020
dc.authorwosidAkkoc, Nurullah/D-9870-2011
dc.contributor.authorKalyoncu, Umut
dc.contributor.authorSolmaz, Dilek
dc.contributor.authorEmmungil, Hakan
dc.contributor.authorYazici, Ayten
dc.contributor.authorKasifoglu, Timucin
dc.contributor.authorKimyon, Gezmis
dc.contributor.authorBalkarli, Ayse
dc.date.accessioned2024-06-12T10:50:51Z
dc.date.available2024-06-12T10:50:51Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Adult-onset Still's disease (AOSD) is a rare condition, and treatment choices are frequently dependent on expert opinions. The objectives of the present study were to assess treatment modalities, disease course, and the factors influencing the outcome of patients with AOSD. Methods: A multicenter study was used to reach sufficient patient numbers. The diagnosis of AOSD was based on the Yamaguchi criteria. The data collected included patient age, gender, age at the time of diagnosis, delay time for the diagnosis, typical AOSD rash, arthralgia, arthritis, myalgia, sore throat, lymphadenopathy, hepatomegaly, splenomegaly, pleuritic, pericarditis, and other rare findings. The laboratory findings of the patients were also recorded. The drugs initiated after the establishment of a diagnosis and the induction of remission with the first treatment was recorded. Disease patterns and related factors were also investigated. A multivariate analysis was performed to assess the factors related to remission. Results: The initial data of 356 patients (210 females; 59%) from 19 centers were evaluated. The median age at onset was 32 (16-88) years, and the median follow-up time was 22 months (0-180). Fever (95.8%), arthralgia (94.9%), typical AOSD rash (66.9%), arthritis (64.6%), sore throat (63.5%), and myalgia (52.8%) were the most frequent clinical features. It was found that 254 of the 306 patients (83.0%) displayed remission with the initial treatment, including corticosteroids plus methotrexate with or without other disease-modifying antirheumatic drugs. The multivariate analysis revealed that the male sex, delayed diagnosis of more than 6 months, failure to achieve remission with initial treatment, and arthritis involving wrist/elbow joints were related to the chronic disease course. Conclusion: Induction of remission with initial treatment was achieved in the majority of AOSD patients. Failure to achieve remission with initial treatment as well as a delayed diagnosis implicated a chronic disease course in AOSD. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jaut.2016.02.010
dc.identifier.endpage63en_US
dc.identifier.issn0896-8411
dc.identifier.issn1095-9157
dc.identifier.pmid26970681en_US
dc.identifier.scopus2-s2.0-84960153857en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.1016/j.jaut.2016.02.010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18157
dc.identifier.volume69en_US
dc.identifier.wosWOS:000374919900006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Autoimmunityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdult-Onset Still's Diseaseen_US
dc.subjectDisease Modifying Anti-Rheumatic Drugsen_US
dc.subjectDisease Patternen_US
dc.subjectRemissionen_US
dc.subjectMethotrexate Treatmenten_US
dc.subjectEfficacyen_US
dc.titleResponse rate of initial conventional treatments, disease course, and related factors of patients with adult-onset Still's disease: Data from a large multicenter cohorten_US
dc.typeArticleen_US

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