Anti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia/reperfusion

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dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.contributor.authorGuzel, Ahmet
dc.contributor.authorKanter, Mehmet
dc.contributor.authorGuzel, Aygul
dc.contributor.authorPergel, Ahmet
dc.contributor.authorErboga, Mustafa
dc.date.accessioned2024-06-12T11:03:57Z
dc.date.available2024-06-12T11:03:57Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the role of infliximab on acute lung injury induced by intestinal ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: sham, I/R and I/R+ infliximab; each group contain 10 animals. Sham group animals underwent laparotomy without I/R injury. After I/R groups animals underwent laparotomy, 1 h of superior mesenteric artery ligation were followed by 1 h of reperfusion. In the infliximab group, 3 days before I/R, infliximab (3 mg/kg) was administered by intravenously. All animals were sacrificed at the end of reperfusion and lung tissues samples were obtained for biochemical and histopathological investigation in all groups. To date, no more biochemical and histopathological changes on intestinal I/R injury in rats by infliximab treatment have been reported. Infliximab treatment significantly decreased the elevated tissue malondialdehyde levels and increased of reduced superoxide dismutase, and glutathione peroxidase enzyme activities in lung tissues samples. Intestinal I/R caused severe histopathological injury including edema, hemorrhage, increased thickness of the alveolar wall and a great number of inflammatory cells that infiltrated the interstitium and alveoli. Infliximab treatment significantly attenuated the severity of intestinal I/R injury. Furthermore, there is a significant reduction in the activity of inducible nitric oxide synthase and arise in the expression of surfactant protein D in lung tissue of acute lung injury induced by intestinal I/R with infliximab therapy. It was concluded that infliximab treatment might be beneficial in acute lung injury, therefore, shows potential for clinical use. Because of its anti-inflammatory and antioxidant effects, infliximab pretreatment may have protective effects in acute lung injury induced by intestinal I/R.en_US
dc.identifier.doi10.1007/s10735-012-9396-0
dc.identifier.endpage369en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue3en_US
dc.identifier.pmid22389028en_US
dc.identifier.scopus2-s2.0-84865630968en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-012-9396-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21855
dc.identifier.volume43en_US
dc.identifier.wosWOS:000307288800013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Ischemia/Reperfusionen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectInos And Surfactant Protein Den_US
dc.subjectInfliximaben_US
dc.subjectRaten_US
dc.subjectMultiple Organ Failureen_US
dc.subjectNitric-Oxideen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectCell-Proliferationen_US
dc.subjectOxidative Stressen_US
dc.subjectAlpha Therapyen_US
dc.subjectFree-Radicalsen_US
dc.subjectProtein-Den_US
dc.subjectInhibitionen_US
dc.subjectAnionen_US
dc.titleAnti-inflammatory and antioxidant effects of infliximab on acute lung injury in a rat model of intestinal ischemia/reperfusionen_US
dc.typeArticleen_US

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