Antioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in rats

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dc.authoridkeles, nursen/0000-0002-6219-1071
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authorwosidkeles, nursen/GWC-9969-2022
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidbulur, sule/X-1314-2019
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorAksu, Feyza
dc.contributor.authorAksu, Burhan
dc.contributor.authorUnlu, Nermin
dc.contributor.authorKaraca, Turan
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorErman, Hayriye
dc.contributor.authorUzun, Hafize
dc.date.accessioned2024-06-12T10:58:26Z
dc.date.available2024-06-12T10:58:26Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractContrast induced nephropathy (CIN) is a major cause of morbidity, and increased costs as well as an increased risk of death. This study was evaluated effects of exogenous sphingosylphosphorylcholine (SPC) administration on CIN in rats. Eight animals were included in each of the following eight groups: control, control phosphate-buffered solution (PBS), control SPC 2, control SPC 10, CIN, CIN PBS, CIN SPC 2 and CIN SPC 10. The induced nephropathy was created by injected with 4g iodine/kg body weight. SPC was administered 3d at a daily two different doses of 2m/mL and 10m/mL intraperitoneally. The severity of renal injury score was determined by the histological and immunohistochemical changes in the kidney. Malondialdehyde (MDA), nitric oxide (NO) and superoxide dismutase (SOD) were determined to evaluate the oxidative status in the renal tissue. Treatment with 2 and 10M SPC inhibited the increase in renal MDA, NO levels significantly and also attenuated the depletion of SOD in the renal injuryCIN. These data were supported by histopathological findings. The inducible nitric oxide synthase positive cells and apoptotic cells in the renal tissue were observed to be reduced with the 2 and 10M SPC treatment. These findings suggested that 2 and 10M doses can attenuate renal damage in contrast nephropathy by prevention of oxidative stress and apoptosis. The low and high dose SPC may be a promising new therapeutic agent for CIN.en_US
dc.identifier.doi10.1080/0886022X.2016.1194142
dc.identifier.endpage1098en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7en_US
dc.identifier.pmid27309733en_US
dc.identifier.scopus2-s2.0-84974777351en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1089en_US
dc.identifier.urihttps://doi.org/10.1080/0886022X.2016.1194142
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20068
dc.identifier.volume38en_US
dc.identifier.wosWOS:000382175000011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectContrast-Induced Nephropathyen_US
dc.subjectNitric Oxideen_US
dc.subjectOxidative Stressen_US
dc.subjectRenal Injuryen_US
dc.subjectSphingosylphosphorylcholineen_US
dc.subjectSmooth-Muscle Contractionen_US
dc.subjectNitric-Oxideen_US
dc.subjectCoronary-Angiographyen_US
dc.subjectSignaling Pathwaysen_US
dc.subjectEndothelial-Cellsen_US
dc.subjectOxidative Stressen_US
dc.subjectKinaseen_US
dc.subjectPathophysiologyen_US
dc.subjectApoptosisen_US
dc.subjectAgentsen_US
dc.titleAntioxidant and renoprotective effects of sphingosylphosphorylcholine on contrast-induced nephropathy in ratsen_US
dc.typeArticleen_US

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