Protective effects of Ginkgo biloba (EGb 761) on testicular torsion/detorsion-induced ischemia-reperfusion injury in rats

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dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:02:38Z
dc.date.available2024-06-12T11:02:38Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effect of Ginkgo biloba (EGb 761) on testicular torsion/detorsion induced ischemia-reperfusion (I/R) injury. A total of 24 male Wistar albino rats were divided into three groups: control, I/R and I/R treated with EGb 761: each group contains 8 animals. Testicular torsion was created by rotating the left testis 720 in a clockwise direction. The ischemia period was 5 h and orchiectomy was performed after 5 h of detorsion. EGb 761 (50 mg/kg, orally) was administrated only once, 40 min prior to detorsion. To date, no more histopathological changes on testicular torsion/detorsion induced ischemia-reperfusion (I/R) injury in rats by EGb 761 treatment have been reported. Spermatogenesis and mean seminiferous tubule diameter (MSTD) were significantly decreased in I/R groups were compared to the control group. Furthermore, EGb 761 treated animals showed an improved histological appearance in I/R group. Our data indicate a significant reduction in the activity of TUNEL and endothelial nitric oxide synthase (eNOS) in testes tissue of I/R treated with EGb 761 therapy. Electron microscopy of the testes of rats demonstrated that EGb 761 pretreatment was particularly effective in preventing the mitochondrial degeneration, dilatation of SER and enlarged intercellular spaces in both Sertoli and spermatid cells in I/R treated animals. We believe that further preclinical research into the utility of EGb 761 may indicate its usefulness as a potential treatment on testes injury after I/R in rats. (C) 2011 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.yexmp.2011.09.003
dc.identifier.endpage713en_US
dc.identifier.issn0014-4800
dc.identifier.issue3en_US
dc.identifier.pmid21930126en_US
dc.identifier.scopus2-s2.0-80053538900en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage708en_US
dc.identifier.urihttps://doi.org/10.1016/j.yexmp.2011.09.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21366
dc.identifier.volume91en_US
dc.identifier.wosWOS:000297714700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofExperimental And Molecular Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGinkgo Bilobaen_US
dc.subjectTesticular Torsionen_US
dc.subjectTUNELen_US
dc.subjectEnosen_US
dc.subjectUltrastructureen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectGerm-Cell Apoptosisen_US
dc.subjectTorsionen_US
dc.subjectTestisen_US
dc.subjectExpressionen_US
dc.subjectTissueen_US
dc.subjectDetorsionen_US
dc.subjectCalpainen_US
dc.subjectSpermen_US
dc.subjectSpermatogenesisen_US
dc.titleProtective effects of Ginkgo biloba (EGb 761) on testicular torsion/detorsion-induced ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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