The utility of maternal serum endocan level to predict preterm delivery within seven days in patients with threatened preterm labor

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dc.authoridMadazli, Riza/0000-0002-6400-1964
dc.authoridAkkaya Fırat, Asuman/0000-0001-7338-3282
dc.authoridÖzel, Aysegül/0000-0002-0283-1049;
dc.authorwosidAlıcı Davutoğlu, Ebru/AIE-5610-2022
dc.authorwosidMadazli, Riza/AAD-3721-2021
dc.authorwosidAkkaya Fırat, Asuman/JAO-5175-2023
dc.authorwosidMadazlı, Rıza/AAA-8734-2020
dc.authorwosidÖzel, Aysegül/ABL-8427-2022
dc.authorwosiddavutoglu, ebru alici/AAD-3181-2021
dc.contributor.authorDavutoglu, Ebru Alici
dc.contributor.authorFirat, Asuman Akkaya
dc.contributor.authorOzel, Aysegul
dc.contributor.authorUzun, Isil
dc.contributor.authorOzer, Nida
dc.contributor.authorMadazli, Riza
dc.date.accessioned2024-06-12T11:00:23Z
dc.date.available2024-06-12T11:00:23Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of the current study was to determine serum endocan levels in patients with threatened preterm labor and to assign whether endocan levels in patients with true preterm labor who give birth within 7 days differ from those of false preterm labor and uncomplicated pregnancy. Materials and methods: This cross-sectional study was conducted on 58 patients diagnosed with threatened preterm labor and 31 healthy pregnant women matched for gestational age. Patients with threatened preterm labor were divided into two groups; preterm delivery (28) and term delivery (30) groups. Maternal serum endocan levels were measured with the use of an enzyme-linked immunosorbent assay kit. Results: The median serum endocan level (pg/mL) in patients with threatened preterm labor was significantly higher than that of women with uncomplicated pregnancies (725, IQR 619-823 versus 310, IQR 218-423; p < .001 Figure 1). Subgroup analysis performed among threatened preterm labor group revealed that median serum endocan level (pg/mL) in preterm delivery group was higher compared with the other two groups (preterm 823, IQR 718-905 versus term 637, IQR 590-729 p < .001 and preterm 823, IQR 718-905 versus control 310, IQR 218-423 p < .001). The threshold value of maternal serum endocan level for predicting delivery within 7 days after admission was calculated 655 pg/mL, (the area under curve was 0.934, 95% CI 0.88-0.98, p < .001) with 85.7% sensitivity and 78.7% specificity. The mean cervical length measurement was significantly higher in the control group (p < .001); there was no significant difference in cervical length between the term and preterm delivery groups. Maternal characteristics including age, BMI, gravidity, gestational age at blood sampling, CRP and Hb levels were not significantly different between groups (p > .05). Conclusions: The maternal serum endocan level may be a useful marker to define high risk group for preterm delivery in patients with threatened preterm labor and similar cervical length measures.en_US
dc.identifier.doi10.1080/14767058.2019.1649388
dc.identifier.endpage1791en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue11en_US
dc.identifier.pmid31434521en_US
dc.identifier.scopus2-s2.0-85071019681en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1786en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2019.1649388
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20804
dc.identifier.volume34en_US
dc.identifier.wosWOS:000482835400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndocanen_US
dc.subjectPredictionen_US
dc.subjectPreterm Deliveryen_US
dc.subjectThreatened Preterm Laboren_US
dc.subjectCell-Specific Molecule-1en_US
dc.subjectBirthen_US
dc.subjectEsm-1en_US
dc.subjectEpidemiologyen_US
dc.subjectInfectionen_US
dc.subjectCytokinesen_US
dc.subjectMortalityen_US
dc.subjectSurvivalen_US
dc.subjectDiseaseen_US
dc.subjectMarkeren_US
dc.titleThe utility of maternal serum endocan level to predict preterm delivery within seven days in patients with threatened preterm laboren_US
dc.typeArticleen_US

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