A Novel Potential Biomarker for Predicting the Development of Septic Embolism in Patients with Infective Endocarditis: Systemic Coagulation Inflammation Index

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dc.contributor.authorOzkan, Ugur
dc.contributor.authorGurdogan, Muhammet
dc.date.accessioned2024-06-12T11:03:51Z
dc.date.available2024-06-12T11:03:51Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Early diagnosis of septic emboli is crucial to prevent the associated morbidity and mortality. This study aimed to examine the relationship between the systemic coagulation inflammation index (SCII) and septic embolism in patients with infective endocarditis (IE). Methods: We retrospectively analyzed the data of 167 IE patients treated at our tertiary care hospital between January 2007 and January 2023. We collected information on symptoms, comorbidities, predisposing valve diseases, prosthetic valves, devices, history of injectable drug use, blood culture results, echocardiographic findings, and complications. The SCII index was calculated using the formula: [platelet count (PLT) x fibrinogen level (g/L) / white blood cell count (WBC)]. Results: The mean age of the patients was 61 years, with rheumatic valve disease being the most common predisposing factor. The most common etiologic microorganism was Staphylococcus species. Septic embolism developed in 25.7% of the patients, with the cerebral system being the most commonly affected (46.5%). The SCII was identified as an independent marker for the development of septic embolism. Receiver operating characteristic (ROC) curve analysis confirmed that an optimal SCII value of 59.8 predicted septic emboli with a sensitivity of 65.1% and a specificity of 59.6% (area under the ROC curve: 0.649 [95% confidence interval (CI): 0.556 - 0.743], P = 0.004). Conclusion: This study demonstrates that high SCII levels are an independent predictor for the development of septic embolism in patients with IE.en_US
dc.identifier.doi10.5543/tkda.2023.30344
dc.identifier.endpage43en_US
dc.identifier.issn1016-5169
dc.identifier.issn1308-4488
dc.identifier.issue1en_US
dc.identifier.pmid38221833en_US
dc.identifier.scopus2-s2.0-85182540039en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2023.30344
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21796
dc.identifier.volume52en_US
dc.identifier.wosWOS:001171834400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives Of The Turkish Society Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfective Endocarditisen_US
dc.subjectSeptic Embolismen_US
dc.subjectSystemic Coagulation Inflammation Indexen_US
dc.subjectEventsen_US
dc.titleA Novel Potential Biomarker for Predicting the Development of Septic Embolism in Patients with Infective Endocarditis: Systemic Coagulation Inflammation Indexen_US
dc.typeArticleen_US

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