Association Between Matrix Metalloproteinase-9 C-1562T Gene Polymorphism and Ischemic Stroke

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dc.authorwosidYILDIZ, Mustafa/P-9934-2015
dc.authorwosidYILDIZ, Mustafa/B-7520-2016
dc.contributor.authorKara, Ismail
dc.contributor.authorSipahi, Tammam
dc.contributor.authorSunal, Asli Sert
dc.contributor.authorYildiz, Mustafa
dc.contributor.authorGuldiken, Baburhan
dc.date.accessioned2024-06-12T11:08:09Z
dc.date.available2024-06-12T11:08:09Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Matrix metalloproteinases (MMPs) are calcium-dependent zinc-containing proteases containing more than 28 enzymes that cause the degrading of the extracellular matrix. Although MMPs play key roles in many biological processes, they influence some pathological processes such as ischemic stroke (IS). Among MMPs, the enzyme most associated with IS is the MMP9 enzyme. This study aimed to evaluate the effect of the C-1562T (rs3918242) gene polymorphism of MMP9 on the development of IS in Turkish patients living in the Trakya Region.Materials and Methods: Our study involved 60 patients with IS and 60 controls. The patients with IS were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment classification of stroke subtypes, and MMP9 C-1652T gene polymorphism was identified using polymerase chain reaction, followed by restriction fragment length polymorphism using the Pael (SphI) restriction enzyme.Results: Genotypes were defined as CC, CT, and TT according to the presence of C and T alleles. No significant differences were identified in the genotype distribution and allele frequency of MMP9 C-1562T gene polymorphism between the patients with IS and controls.Conclusion: Our findings suggest that MMP9 C-1562T gene polymorphism is not associated with the risk of IS in Turkish patients living in the Trakya Region.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [2017/55]en_US
dc.description.sponsorshipFinancial Disclosure: The study was supported by Trakya University Scientific Research Projects Unit with project grant number (2017/55) .en_US
dc.identifier.doi10.4274/tnd.2023.83641
dc.identifier.endpage194en_US
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85174004549en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage190en_US
dc.identifier.urihttps://doi.org/10.4274/tnd.2023.83641
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22313
dc.identifier.volume29en_US
dc.identifier.wosWOS:001102709400005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal Of Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMatrix Metalloproteinaseen_US
dc.subjectStrokeen_US
dc.subjectMMP9en_US
dc.subjectC-1562Ten_US
dc.subjectRs3918242en_US
dc.subjectPromoter Polymorphismsen_US
dc.subjectMatrixen_US
dc.subjectSusceptibilityen_US
dc.subjectBrainen_US
dc.titleAssociation Between Matrix Metalloproteinase-9 C-1562T Gene Polymorphism and Ischemic Strokeen_US
dc.typeArticleen_US

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