Could Fluorescein Staining in Low-Grade Glial Tumors Guide for Peroperative Differentiation of Pathological Types?

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dc.authoridBayatli, Eyup/0000-0001-6246-4247
dc.authoridZaimoglu, Murat/0000-0001-5330-1251
dc.authorwosidBayatli, Eyup/AGH-1317-2022
dc.authorwosidZaimoglu, Murat/ABA-1332-2022
dc.contributor.authorOzden, Mahmut
dc.contributor.authorMammadkhanli, Orkhan
dc.contributor.authorZaimoglu, Murat
dc.contributor.authorBayatli, Eyup
dc.contributor.authorBozkurt, Melih
dc.date.accessioned2024-06-12T11:02:42Z
dc.date.available2024-06-12T11:02:42Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAIM: To define whether characteristics of fluorescein staining help to distinguish low grade gliomas intraoperatively.MATERIAL and METHODS: We studied 46 patients with supratentorial newly diagnosed noncontrast-enhancing LGGs removed by fluorescence guidance under the YELLOW 560 nm filter. Patients who were treated between July 2019 and 2022 were retrospectively analyzed. Clinical data were collected from patient records. Patients' intraoperative video recordings, pathological examination, and preoperative magnetic resonance imaging (MRI) were analyzed and compared for each patient after the operation. Histopathologically, patients were divided into WHO Grade 2 oligodendrogliomas, diffuse astrocytomas (IDH mutant, 1p19q negative tumors), and pre-glioblastomas (IDH wild type, 1p19q negative tumors). Resection margins were checked using controls contrast -enhanced cranial MRI at the postoperative 24 and72 hours.RESULTS: Our observations indicate that fluorescein primarily stains diffuse astrocytomas (IDH mutant, 1p19q negative tumors) and pre-glioblastomas (IDH wild type, 1p19q negative tumors) rather than WHO Grade 2 oligodendrogliomas.CONCLUSION: Fluorescein staining might be an option to determine tumor borders in WHO Grade 2 glial tumors, particularly for those with a higher malignancy potential.en_US
dc.identifier.doi10.5137/1019-5149.JTN.42622-22.2
dc.identifier.endpage854en_US
dc.identifier.issn1019-5149
dc.identifier.issue5en_US
dc.identifier.pmid37309632en_US
dc.identifier.scopus2-s2.0-85171666141en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage847en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.42622-22.2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21383
dc.identifier.volume33en_US
dc.identifier.wosWOS:001110014100012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGliomaen_US
dc.subjectFluoresceinen_US
dc.subjectIsocitrate Dehydrogenaseen_US
dc.subjectSodium Fluoresceinen_US
dc.subjectBrain-Tumorsen_US
dc.subjectResectionen_US
dc.subjectSurgeryen_US
dc.subjectGliomasen_US
dc.titleCould Fluorescein Staining in Low-Grade Glial Tumors Guide for Peroperative Differentiation of Pathological Types?en_US
dc.typeArticleen_US

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