Spinal cord ependymomas in adults: Analysis of 15 cases

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dc.authorscopusid6603957040
dc.authorscopusid6602108710
dc.authorscopusid6701857906
dc.authorscopusid6506523119
dc.authorscopusid11540009300
dc.contributor.authorKocak Z.
dc.contributor.authorGaripagaoglu M.
dc.contributor.authorAdli M.
dc.contributor.authorUzal M.C.
dc.contributor.authorKurtman C.
dc.date.accessioned2024-06-12T10:28:08Z
dc.date.available2024-06-12T10:28:08Z
dc.date.issued2004
dc.description.abstractThis retrospective analysis was performed to examine the outcome of patients with spinal cord ependymomas treated with surgery and postoperative radiation therapy between 1982 and 1998. There were 10 male and 5 female patients, ranging from 16 to 74 years of age with a median age of 38 years. Surgery was gross total resection in 2 patients, subtotal resection in 10, biopsy in 3. All patients received radiation therapy with a total dose of 40-56 Gy. The 5 and 10 year overall survival rates were 83.3 and 83.3%, respectively. Twelve patients are still alive at a median follow-up period of 70 months. Of the 15 patients, 6 developed recurrent disease on follow-up. The median time to recurrence was 45 months (range: 24-80 months). Local failure within the initial irradiated volume occurred in 3 out of 6 patients who received less than 45 Gy and 2 out of 8 patients treated with more than 45 Gy. Four out of the six failures were salvaged with additional treatment. Re-irradiation was used as a part of salvage or sole treatment in 3 cases. The patient who was salvaged with radiation therapy only died of disease progression 41 months following recurrence and the other two who received a combination of surgery, radiotherapy or chemotherapy were still alive 57 and 30 months following relapse. The present study shows that surgery and post-operative radiation treatment for spinal ependymoma patients resulted in high survival rates. Patients with residual disease after surgery should be treated with radiation therapy with a dose of more than 45 Gy. Re-irradiation may be the treatment of choice for recurrent patients having less than complete resection or no surgery.en_US
dc.identifier.endpage206en_US
dc.identifier.issn0392-9078
dc.identifier.issue2en_US
dc.identifier.pmid15354403en_US
dc.identifier.scopus2-s2.0-3242687097en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17092
dc.identifier.volume23en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Experimental and Clinical Cancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpendymomas; Radiotherapy; Spinal Corden_US
dc.subjectAntineoplastic Agent; Adolescent; Adult; Aged; Article; Cancer Recurrence; Cancer Survival; Clinical Article; Ependymoma; Female; Follow Up; Human; Male; Minimal Residual Disease; Postoperative Care; Priority Journal; Radiation Dose; Retrospective Study; Salvage Therapy; Spinal Cord Biopsy; Spinal Cord Ependymoma; Treatment Indication; Treatment Outcome; Adolescent; Adult; Aged; Ependymoma; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Retrospective Studies; Salvage Therapy; Spinal Cord Neoplasms; Survival Rate; Treatment Outcomeen_US
dc.titleSpinal cord ependymomas in adults: Analysis of 15 casesen_US
dc.typeArticleen_US

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