The Role of Interferons in Cardiac Remodeling after Acute Myocardial Infarction

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dc.authoridGök, Murat/0000-0003-3118-9064
dc.authoridÖZKAN, CAN/0000-0001-6255-711X
dc.authoridKoçak, Ajar/0000-0002-4262-7157
dc.authorwosidGök, Murat/AAZ-3324-2021
dc.authorwosidÖZKAN, CAN/HKM-4224-2023
dc.authorwosidKoçak, Ajar/AAE-4606-2022
dc.contributor.authorEyyupkoca, Ferhat
dc.contributor.authorEyerci, Nilnur
dc.contributor.authorOzkan, Can
dc.contributor.authorKocak, Ajar
dc.contributor.authorGok, Murat
dc.contributor.authorErcan, Karabekir
dc.date.accessioned2024-06-12T10:55:43Z
dc.date.available2024-06-12T10:55:43Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To determine the relationship of serial interferon (IFN) measurements and adverse cardiac remodeling (AR) after myocardial infarction (MI). Study Design: Observational multi-centre study. Place and Duration of Study: Departments of Cardiology of Diskapi Yildirim Beyazit Training and Research Hospital, Ataturk Training and Research Hospital, Numune Training and Research Hospital, and Dr. Nafiz Sincan Korez State Hospital, Turkey, from June 2015 to June 2020. Methodology: Forty-seven patients with acute MI were included. IFN levels were measured on the first day and at 14 days and 45 days post-MI. Reverse cardiac remodeling (RR) and AR were defined as the reduction of left ventricular end-diastolic volume by-12% and increases of-12% by cardiac magnetic resonance imaging at the 6-month follow-up. Statistical significance was accepted as p<0.05. Results: Median IFN-alpha (50.1 vs. 34.8 pg/mL, p=0.035), IFN-beta (39.1 vs. 23.0 pg/mL, p=0.013), and IFN-gamma (26.7 vs. 18.5 pg/mL, p=0.023) levels on the first day post-MI were higher in the AR group compared to the RR group. At 14 days post-MI, IFN levels had decreased in the AR group, while they had not changed in the RR group. At 45 days post-MI, IFN levels were similar between the AR and RR groups. High IFN-alpha level on the first-day post-MI was an independent predictor of AR (OR: 1.23, 95% CI: 1.06-1.43, p=0.008). Conclusion: High IFN levels in the acute phase post-MI are associated with AR. Among IFNs, IFN-alpha is an important predictor of AR. Stable IFN levels appear to be associated with cardiac healing.en_US
dc.description.sponsorshipMinistry of Health of the Republic of Turkey (Department of Research, Development, and Health Technology Evaluation) [2015/SAGEM-2/001]en_US
dc.description.sponsorshipThe authors declared that this research received financial support from the Ministry of Health of the Republic of Turkey (Department of Research, Development, and Health Technology Evaluation) via the 2015/SAGEM-2/001 project.en_US
dc.identifier.doi10.29271/jcpsp.2022.07.837
dc.identifier.endpage842en_US
dc.identifier.issn1022-386X
dc.identifier.issn1681-7168
dc.identifier.issue7en_US
dc.identifier.pmid35795928en_US
dc.identifier.scopus2-s2.0-85133646167en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage837en_US
dc.identifier.urihttps://doi.org/10.29271/jcpsp.2022.07.837
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19530
dc.identifier.volume32en_US
dc.identifier.wosWOS:000822704300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherColl Physicians & Surgeons Pakistanen_US
dc.relation.ispartofJcpsp-Journal Of The College Of Physicians And Surgeons Pakistanen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiac Remodelingen_US
dc.subjectInterferonsen_US
dc.subjectInflammationen_US
dc.subjectMyocardial Infarctionen_US
dc.subjectI Interferonsen_US
dc.titleThe Role of Interferons in Cardiac Remodeling after Acute Myocardial Infarctionen_US
dc.typeArticleen_US

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