Investigation of mutations in the synaptonemal complex protein 3 (SYCP3) gene among azoospermic infertile male patients in the Turkish population

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authoridPalanduz, Sukru/0000-0002-9435-009X
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidKadioglu, Ates/AAV-6720-2020
dc.authorwosidPalanduz, Sukru/AAC-6863-2020
dc.contributor.authorGurkan, H.
dc.contributor.authorAydin, F.
dc.contributor.authorKadioglu, A.
dc.contributor.authorPalanduz, S.
dc.date.accessioned2024-06-12T11:08:02Z
dc.date.available2024-06-12T11:08:02Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTo investigate possible mutations and/or single nucleotide polymorphisms in the synaptonemal complex protein 3 (SYCP3) gene among nonobstructive azoospermic infertile males in a Turkish population, 75 nonobstructive azoospermic infertile male patients were included in the study. These patients were unrelated to each other and had 46,XY chromosome structure without Y microdeletion. In addition, 75 individuals whose fertility was proven by reproduction were enrolled in the study as controls. Nine exon deep intronic primers belonging to the SYCP3 gene were designed and amplified by PCR, and the nucleotide sequences were identified by DNA sequence analysis. DNA sequence analysis was used to detect mutations and/or single nucleotide polymorphisms in the SYCP3 gene. No mutations were detected in the 9 exons of SYCP3. A total of eleven variations, however, were detected: seven have been identified in the NCBI SNP database, whereas four have not. On the basis of the results, we agree with the idea that SYCP3 mutations are not associated with the genetic susceptibility for meiotic arrest in infertile male patients with nonobstructive azoospermia in the Turkish population and that further studies investigating the other components of the synaptonemal complex protein (SYCP1, SYCP2) should be conducted.en_US
dc.identifier.doi10.1111/j.1439-0272.2012.01317.x
dc.identifier.endpage100en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue2en_US
dc.identifier.pmid22670862en_US
dc.identifier.scopus2-s2.0-84874270198en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1111/j.1439-0272.2012.01317.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22280
dc.identifier.volume45en_US
dc.identifier.wosWOS:000315398900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMale Infertilityen_US
dc.subjectSingle Nucleotide Polymorphismen_US
dc.subjectSynaptonemal Complex Protein 3en_US
dc.subjectY Chromosome Microdeletionsen_US
dc.subjectRna Secondary Structureen_US
dc.subjectOligozoospermiaen_US
dc.titleInvestigation of mutations in the synaptonemal complex protein 3 (SYCP3) gene among azoospermic infertile male patients in the Turkish populationen_US
dc.typeArticleen_US

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