Investigation of differences of sacral and vertebral bone mineral densities before and after radiotherapy in patients with locally advanced rectal cancer

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dc.authorwosidUZAL, Mustafa Cem/AAH-2683-2019
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.contributor.authorHayar, M.
dc.contributor.authorDurankus, N. K.
dc.contributor.authorAltun, G. D.
dc.contributor.authorKocak, Z.
dc.contributor.authorUzal, M. C.
dc.contributor.authorSaynak, M.
dc.date.accessioned2024-06-12T11:13:26Z
dc.date.available2024-06-12T11:13:26Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose. - Radiotherapy is a treatment method performed using ionizing radiation on cancer patients either alone or with surgery and/or chemotherapy. Although modern radiotherapy techniques provide a significant advantage in protecting healthy tissues, it is inevitable that normal tissues are also located in the areas targeted by radiations. In this study, we aimed to examine the bone mineral density changes in bone structures commonly included in the irradiated area such as, L5 vertebra, sacrum, and femur heads, in patients who have received pelvic radiotherapy; and the relationship between these changes with radiation dose. Material and methods. - Patients included in the study had been previously diagnosed with rectal cancer, which were operated or not. Preoperative or postoperative pelvic radiotherapy was planned for all patients. In terms of convenience when comparing with future scans, all densitometry and CT scans were performed with the same devices. Fifteen patients were included in the study. In order to determine the dose of radiation each identified area had taken after radiotherapy, the sacrum, L5 vertebra, bilateral femoral heads, and L1 regions were contoured in the CT scans in which treatment planning was done. Sagittal cross-sectional images were taken advantage of while these regions were being contoured. Results. - Bone mineral density was evaluated with CT and dual-energy X-ray absorptiometry before and after the treatment. The regions that have theoretically been exposed to irradiation, such as L5, sacrum, left to right femur were found to have significant difference in terms of bone density. According to CT evaluation, there was a significant decrease in bone intensity of L5, sacrum, left and right femurs. Dual energy X-ray absorptiometry assessment revealed that the whole of the left femoral head, left femur neck and Ward's region were significantly affected by radiotherapy. However, there was no significant difference in the sacrum and L5 vertebra before and after radiotherapy. Conclusion. - More accurate results could be achieved if the same study was conducted on a larger patient population, with a longer follow-up period. When the reduction in bone density is at maximum or a cure is likely in a long-term period, bone mineral density could be determined by measurements performed at regular intervals. (C) 2019 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.canrad.2019.05.014
dc.identifier.endpage415en_US
dc.identifier.issn1278-3218
dc.identifier.issn1769-6658
dc.identifier.issue5en_US
dc.identifier.pmid31331841en_US
dc.identifier.scopus2-s2.0-85069046969en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage408en_US
dc.identifier.urihttps://doi.org/10.1016/j.canrad.2019.05.014
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23554
dc.identifier.volume23en_US
dc.identifier.wosWOS:000487346000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofCancer Radiotherapieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRectumen_US
dc.subjectCanceren_US
dc.subjectRadiotherapyen_US
dc.subjectPelvicen_US
dc.subjectBoneen_US
dc.subjectDensityen_US
dc.subjectInduced Insufficiency Fracturesen_US
dc.subjectCervical-Canceren_US
dc.subjectPelvic Radiotherapyen_US
dc.subjectRadiation-Therapyen_US
dc.subjectOsteoporosisen_US
dc.subjectIrradiationen_US
dc.subjectWomenen_US
dc.subjectWomanen_US
dc.subjectRisken_US
dc.titleInvestigation of differences of sacral and vertebral bone mineral densities before and after radiotherapy in patients with locally advanced rectal canceren_US
dc.typeArticleen_US

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