Prognostic importance of central thrombus in hemodynamically stable patients with pulmonary embolism

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dc.authoridKoçak, Nagihan Dumuş/0000-0003-4028-2797
dc.authoridŞentürk, Ayşegül/0000-0002-1072-0592
dc.authoridDemir, Nalan/0000-0002-3168-9176
dc.authoridDemirdöğen, Ezgi/0000-0002-7400-9089
dc.authoridKayhan, Servet/0000-0003-4226-2781
dc.authoridDemirdöğen, Ezgi/0000-0002-7400-9089
dc.authoridŞaylan, Bengü/0000-0002-5922-0847
dc.authorwosidKoçak, Nagihan Dumuş/AFM-4219-2022
dc.authorwosidŞentürk, Ayşegül/CAF-0331-2022
dc.authorwosidDemir, Nalan/ABE-7641-2022
dc.authorwosidDemirdöğen, Ezgi/JPK-7012-2023
dc.authorwosidKayhan, Servet/C-1712-2012
dc.authorwosidDemirdöğen, Ezgi/AAH-9812-2021
dc.authorwosidŞaylan, Bengü/AAU-9251-2020
dc.contributor.authorSenturk, Aysegul
dc.contributor.authorOzsu, Savas
dc.contributor.authorDuru, Serap
dc.contributor.authorCakir, Ebru
dc.contributor.authorUlasli, Sevinc Sarinc
dc.contributor.authorDemirdogen, Ezgi
dc.contributor.authorKayhan, Servet
dc.date.accessioned2024-06-12T11:13:08Z
dc.date.available2024-06-12T11:13:08Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The association between mortality and localization of central thrombus in hemodynamically stable patients with pulmonary embolism (PE) is unclear. Sufficient data are not available to help clinicians to select between low molecular weight heparin (LMWH), unfractionated heparin (UFH) and thrombolytics for the management of central thrombus. The present study aims to investigate whether central thrombus in the pulmonary artery affects 30-day mortality rate, and to compare the outcomes of different treatment approaches in patients with central thrombus. Methods: This multi-central, prospective, observational study included 874 hemodynamically stable patients with PE confirmed by multidetector computed tomography scan. The localization of the emboli was evaluated and categorized as central (saddle or at least one main pulmonary artery), lobar or distal. The primary study outcome was 30-day all-cause mortality. Results: Localization of the emboli was central in 319 (36.5%) patients, lobar in 264 (30.2%) and distal in 291 (33.2%) patients. Seventy-four (8.5%) patients died during the 30-day follow-up period. All-cause mortality rate was 11.9%, 6.8% and 6.2% in patients with central, lobar, and distal emboli, respectively (p < 0.001). Multivariate analysis did not show that hemodynamically stable central thrombus was an independent predictor of mortality. Additionally, mortality rate was not significantly different between UFH, LMWH and thrombolytic therapy groups. Conclusions: The present study showed that central thrombus was not an independent predictor of mortality in hemodynamically stable PE patients. LMWH and UFH were similarly effective in the treatment of this patient group.en_US
dc.identifier.doi10.5603/CJ.a2017.0021
dc.identifier.endpage514en_US
dc.identifier.issn1897-5593
dc.identifier.issn1898-018X
dc.identifier.issue5en_US
dc.identifier.pmid28248408en_US
dc.identifier.scopus2-s2.0-85032821563en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage508en_US
dc.identifier.urihttps://doi.org/10.5603/CJ.a2017.0021
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23435
dc.identifier.volume24en_US
dc.identifier.wosWOS:000414152700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofCardiology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary Embolismen_US
dc.subjectMultidetector Computed Tomographyen_US
dc.subjectCentral Thrombusen_US
dc.subjectAnticoagulationen_US
dc.subjectMortalityen_US
dc.subjectRisk Stratificationen_US
dc.subjectEmergency-Departmenten_US
dc.subjectMultidetector Cten_US
dc.subjectTherapyen_US
dc.subjectThrombolysisen_US
dc.subjectMetaanalysisen_US
dc.subjectCombinationen_US
dc.subjectBiomarkersen_US
dc.subjectHeparinen_US
dc.subjectBurdenen_US
dc.titlePrognostic importance of central thrombus in hemodynamically stable patients with pulmonary embolismen_US
dc.typeArticleen_US

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