The evaluation of risk factors leading to early deaths in patients with acute promyelocytic leukemia: a retrospective study

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dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridatli, emine ikbal/0000-0001-9003-1449
dc.authoridHUNUTLU, FAZIL CAGRI/0000-0002-4991-9830
dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authoridPinar, Ibrahim Ethem/0000-0001-9907-1498
dc.authoridAlp Kirkizlar, Tugcan/0000-0002-1361-6213
dc.authoridDemirci, Ufuk/0000-0001-6923-1470
dc.authorwosidPinar, Ibrahim Ethem/KHE-5423-2024
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.authorwosidatli, emine ikbal/AAN-5060-2020
dc.authorwosidAlp Kirkizlar, Tugcan/HMD-4249-2023
dc.authorwosidHUNUTLU, FAZIL CAGRI/KCK-7512-2024
dc.authorwosidPınar, İbrahim/JWP-2738-2024
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.contributor.authorBaysal, Mehmet
dc.contributor.authorGursoy, Vildan
dc.contributor.authorHunutlu, Fazil Cagri
dc.contributor.authorErkan, Buket
dc.contributor.authorDemirci, Ufuk
dc.contributor.authorBas, Volkan
dc.contributor.authorGulsaran, Sedanur Karaman
dc.date.accessioned2024-06-12T10:50:36Z
dc.date.available2024-06-12T10:50:36Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAcute promyelocytic leukemia (APL) differs from other forms of acute myeloid leukemia (AML), including coagulopathy, hemorrhage, disseminated intravascular coagulation (DIC), and treatment success with all-trans retinoic acid (ATRA). Despite ATRA, early deaths (ED) are still common in APL. Here, we evaluated factors associated with ED and applicability of scoring systems used to diagnose DIC. Ninety-one APL patients (55 females, 36 males, and median age 40 years) were included. ED was defined as deaths attributable to any cause between day of diagnosis and following 30th day. DIC was assessed based on DIC scoring system released by the International Society of Thrombosis and Hemostasis (ISTH) and Chinese Diagnostic Scoring System (CDSS). Patients' median follow-up time was 49.2 months, and ED developed in 14 (15.4% of) cases. Patients succumbing to ED had higher levels of the Eastern Cooperative Oncology Group Performance Status (ECOG PS), lactate dehydrogenase (LDH), and ISTH DIC, and lower fibrinogen levels (p <0.05). In multivariate Cox regression analysis, age >55 and ECOG PS >= 2 rates were revealed to be associated with ED. Based on ISTH and CDSS scores, DIC was reported in 47.3 and 58.2% of the patients, respectively. Despite advances in APL, ED is still a major obstacle. Besides the prompt recognition and correction of coagulopathy, those at high ED risk are recommended to be detected rapidly. Implementation of local treatment plans and creating awareness should be achieved in hematological centers. Common utilization of ATRA and arsenic trioxide (ATO) may be beneficial to overcome ED and coagulopathy in APL patients.en_US
dc.identifier.doi10.1007/s00277-022-04798-8
dc.identifier.endpage1057en_US
dc.identifier.issn0939-5555
dc.identifier.issn1432-0584
dc.identifier.issue5en_US
dc.identifier.pmid35190843en_US
dc.identifier.scopus2-s2.0-85124895216en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1049en_US
dc.identifier.urihttps://doi.org/10.1007/s00277-022-04798-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18064
dc.identifier.volume101en_US
dc.identifier.wosWOS:000759026600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Promyelocytic Leukemiaen_US
dc.subjectCoagulopathyen_US
dc.subjectDisseminated Intravascular Coagulationen_US
dc.subjectEarly Deathen_US
dc.subjectTrans-Retinoic Aciden_US
dc.subjectRemission Inductionen_US
dc.subject15-17 Translocationen_US
dc.subjectTransretinoic Aciden_US
dc.subjectClinical-Featuresen_US
dc.subjectAtraen_US
dc.subjectTherapyen_US
dc.subjectMulticenteren_US
dc.subjectManagementen_US
dc.subjectSurvivalen_US
dc.titleThe evaluation of risk factors leading to early deaths in patients with acute promyelocytic leukemia: a retrospective studyen_US
dc.typeArticleen_US

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