SINGLE AND COMBINED TOXICITY OF ALUMINIUM AN AZORUBINE: PHYSIOLOGICAL AND GENETIC RESPONSES OF DROSOPHILA MELANOGASTER

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dc.authoridKAHRAMAN ILIKKAN, ÖZGE/0000-0001-5843-6868
dc.authoridDoganlar, Zeynep Banu/0000-0002-1365-9897;
dc.authorwosidKAHRAMAN ILIKKAN, ÖZGE/Q-9641-2019
dc.authorwosidDoganlar, Zeynep Banu/B-4845-2008
dc.authorwosidDoğanlar, Oğuzhan/A-2315-2019
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorOngoren, Gulin
dc.contributor.authorKahraman, Ozge
dc.contributor.authorAltinoluk, Pinar
dc.contributor.authorKirbas, Asude
dc.date.accessioned2024-06-12T11:02:34Z
dc.date.available2024-06-12T11:02:34Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study aimed that investigation of the toxic effects of Aluminum (Al) and Azorubine. Adult D. melanogaster flies were treated with Al (100, 200 and 400 ppb) and Azorubine (50 ppm) at both single and combined for 1 and 5 days. The concentrations were selected based on permitted limits in drinking water for Al (200 ppb) and food for Azorubine (50 ppm), respectively. The accumulations of Al and Azorubine, mRNA levels of antioxidant enzymes (superoxide dismutase, catalase and glutathione synthase), heat shock proteins (HSP26, 60, 70 and 83) as well as octopamine levels were determined. RAPD analysis was also performed in order to determine genomic template stability (GTS%). Azorubine addition caused increasing take up the Al, decreasing expressions of antioxidant enzymes and changes in the HSP expression patterns. GTS was decreased with the increased treatment time. The minimum GTS was determined at the 400 ppb Al and Azorubine alone treatment at the both exposure time. The higher increase of the octopamine (4.83 fold) was determined at the 100 ppb Al+Azorubine and 400 ppb Al+Azorubine (3.73 -fold) at the fifth day. We conclude that permitted limits of Al and Azorubine (both single and combined) may cause toxic effects on molecular and physiological level.en_US
dc.description.sponsorshipTrakya University Research Project Foundation, Edirne/Turkey [TUBAP-2015/9]; T.R. State Planning Organization [2011K120390]en_US
dc.description.sponsorshipThis study was supported by Trakya University Research Project Foundation (Project Number: TUBAP-2015/9), Edirne/Turkey. The authors thanks to Technology Research and Application Centre (TUTAGEM), which is funded by T.R. State Planning Organization (Project Number: 2011K120390) for some analysis.en_US
dc.identifier.endpage2946en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue4en_US
dc.identifier.startpage2936en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21337
dc.identifier.volume26en_US
dc.identifier.wosWOS:000400806100057en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenotoxicityen_US
dc.subjectAzorubineen_US
dc.subjectAluminium Toxicityen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectHeat Shock Proteinsen_US
dc.subjectRAPDen_US
dc.subjectMrna Expressionen_US
dc.subjectAmplified Polymorphic Dnaen_US
dc.subjectOxidative Stress Markersen_US
dc.subjectHeat-Shock Proteinsen_US
dc.subjectProtective Roleen_US
dc.subjectIn-Vitroen_US
dc.subjectBiochemical Parametersen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectFood Colorantsen_US
dc.subjectRos Generationen_US
dc.subjectDaphnia-Magnaen_US
dc.titleSINGLE AND COMBINED TOXICITY OF ALUMINIUM AN AZORUBINE: PHYSIOLOGICAL AND GENETIC RESPONSES OF DROSOPHILA MELANOGASTERen_US
dc.typeArticleen_US

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