Adding concurrent low dose continuous infusion of cisplatin to radiotherapy in locally advanced cervical carcinoma
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
British Inst Radiology
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The tolerability and efficacy of the continuous infusion of cisplatin during radiotherapy was studied by tumour response, survival and pelvic control, in carcinoma of the cervix. 44 patients with stage IIB-IIIB cervical carcinoma were prospectively randomized into two groups: radiation alone (control group) versus radiation plus cisplatin (study group). While there was no significant difference in diarrhoea and urinary complication scores, emesis and appetite changes were significantly greater in the study group. Tumour responses were no different at the end of the treatment and 3 months after completion of treatment. After 40 months median follow-up, 40/44 patients were assessed (one had a second primary tumour and three were lost to follow-up). Persistent disease was found in 3 patients: one in the study arm and two in the control arm. Recurrence was seen in 10 patients in the first 2 years. 5-year pelvic control rates were; 69.41/0 and 63.91/0 (p = 0.7), survival rates were 52.0% and 48.9% (p = 0.7) and disease-free survival rates were 67.5% and 58.7% (p = 0.3) for the control and the study groups, respectively. Although the continuous infusion of cisplatin during radiotherapy was well tolerated, this additional treatment did not appear to show an improvement in pelvic control, survival, or disease-free survival.
Açıklama
Anahtar Kelimeler
Squamous-Cell Carcinoma, Gynecologic-Oncology-Group, Pelvic Radiation-Therapy, Stage-Iiib Carcinoma, Term Follow-Up, Uterine Cervix, Radical Radiotherapy, Rate Brachytherapy, Advanced Cancer, Treatment Time
Kaynak
British Journal Of Radiology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
77
Sayı
919
